Reaction between 1,10-phenanthroline and platinum(II) compounds. I. Reaction in aqueous solution

Palocsay, Frank A.; Rund, John V.

doi:10.1021/ic50073a022

Cited by 85 publications

(22 citation statements)

References 1 publication

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“…17) [Pt(bpy)(cbdca)]: [Pt(bpy)Cl 2 ] (420 mg, 1 mmol) was suspended in 100 ml double distilled water and 19.7 ml of 0.10 M AgNO 3 (1.97 mmol) solution was added to it with constant stirring. This mixture was heated at 60°C with stirring under dark for 6 h at 55°C and then 16 h at room temparature (28°C).…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.

2001

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Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.

2001

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“…[Pt(bpy)Cl 2 ] and [Pd(bpy)Cl 2 ] were prepared by the procedures described in the literature. 20 All the experiments involving interaction of the complexes with CT-DNA were performed in Tris-HCl buffer (20 mM) of pH 7.0 medium containing 20 mM NaCl. Sodium salt was used to adjust the ionic strength of the solution.…”

Section: Methodsmentioning

confidence: 99%

DNA-Binding and Thermodynamic Parameters, Structure and Cytotoxicity of Newly Designed Platinum(II) and Palladium(II) Anti-Tumor Complexes

Mansouri‐Torshizi

Saeidifar²,

Khosravi³

et al. 2011

Bulletin of the Korean Chemical Society

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The complexes [Pd(bpy)(Hex-dtc)]NO 3 and [Pt(bpy)(Hex-dtc)]NO 3 (bpy is 2,2'-bipyridine and Hex-dtc is hexyldithiocarbamato ligands) were synthesized and characterized by elemental analysis and spectroscopic studies. The cytotoxicity assay of the complexes has been performed on chronic myelogenous leukemia cell line, K562, at micromolar concentration. Both complexes showed cytotoxic activity far better than that of cisplatin under the same experimental conditions. The binding parameters of the complexes with calf thymus DNA (CT-DNA) was investigated using UV-visible and fluorescence techniques. They show the ability of cooperatively intercalating in CT-DNA. Gel filtration studies demonstrated that platinum complex could cleave the DNA. In the interaction studies between the Pd(II) and Pt(II) complexes with CT-DNA, several binding and thermodynamic parameters have been determined, which may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.

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“…[Pd(phen)Cl 2 ] were prepared by the procedures described in the literature. 15 Piperidine dithiocarbamate sodium salt (pip-dtcNa) and morpholine dithiocarbamate sodium salt (mor-dtcNa) was synthesized in our laboratory. 16,17 All the experiments involving interaction of the complexes with CT-DNA were performed in Tris-HCl buffer (20 mM) of pH=7.0 medium containing 20 mM NaCl.…”

Section: Methodsmentioning

confidence: 99%

DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives

Mansouri‐Torshizi

Saeidifar²,

Ghasemi³

et al. 2011

Journal of the Korean Chemical Society

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, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, 1 H NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show IC50 values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

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Reaction between 1,10-phenanthroline and platinum(II) compounds. I. Reaction in aqueous solution

Cited by 85 publications

References 1 publication

Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.

Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.

DNA-Binding and Thermodynamic Parameters, Structure and Cytotoxicity of Newly Designed Platinum(II) and Palladium(II) Anti-Tumor Complexes

DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives

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