The proposed approach seemed to be suitable for aiding in automatic PD diagnosis by means of computer vision and machine learning techniques. Also, meander images play an important role, leading to higher accuracies than spiral images. We also observed that the main problem in detecting PD is the patients in the early stages, who can draw near-perfect objects, which are very similar to the ones made by control patients.

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Due to the non-stop and rapid spreading of virus pandemics all over the world, traditional healthcare monitoring capabilities of hospitals and/or medical centers are under a severe over-load. Modern computing infrastructures with the harmony of various layers of computing paradigms (e.g., cloud/fog/edge computing) for healthcare monitoring are apparently the essential computing backbone that help access and process instantly the medical data of every single patient at the very edge of the healthcare system to combat with global or regional virus contagion. Previous studies proposed different computing system architectures for healthcare monitoring but few works considered the evaluation of pure performance of medical data transmission in a comprehensive manner. In this paper, we proposed an M/M/c/K queuing network model for the performance evaluation of an Internet of Healthcare Things (IoHT) infrastructure in association with a three layer cloud/fog/edge computing continuum. The model considers a life cycle of medical data from body-attached IoT sensors in edge layer all the way to local clients (e.g., local medical doctors, physicians) through fog layer and to remote clients (e.g., medical professionals, patient's family members) through cloud layer. Furthermore, we also explore the impact of the alteration in system configuration and computing capability of computing layers in two scenarios on various performance metrics. Critical performance metrics related to quality of service are evaluated in a comprehensive manner, such as (i) mean response time of medical data transmission to fog (local) clients and to cloud (remote) clients, (ii) utilization of cloud/fog/edge computing layers, (iii) service throughput, (iv) number of medical messages in a period of time, and (v) drop rate. The simulation results pinpoint bottle-neck parameters and configurations of the IoHT infrastructure's system architecture in relation to the frequency of medical data collection for health check of patients. Thus, the findings of this study can help improve medical administration in hospitals and healthcare centers and help design computing infrastructures in accordance for medical monitoring in the severe circumstances of virus pandemics.

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The aggressive waves of ongoing world-wide virus pandemics urge us to conduct further studies on the performability of local computing infrastructures at hospitals/medical centers to provide a high level of assurance and trustworthiness of medical services and treatment to patients, and to help diminish the burden and chaos of medical management and operations. Previous studies contributed tremendous progress on the dependability quantification of existing computing paradigms (e.g., cloud, grid computing) at remote data centers, while a few works investigated the performance of provided medical services under the constraints of operational availability of devices and systems at local medical centers. Therefore, it is critical to rapidly develop appropriate models to quantify the operational metrics of medical services provided and sustained by medical information systems (MIS) even before practical implementation. In this paper, we propose a comprehensive performability SRN model of an edge/fog based MIS for the performability quantification of medical data transaction and services in local hospitals or medical centers. The model elaborates different failure modes of fog nodes and their VMs under the implementation of fail-over mechanisms. Sophisticated behaviors and dependencies between the performance and availability of data transactions are elaborated in a comprehensive manner when adopting three main load-balancing techniques including: (i) probability-based, (ii) random-based and (iii) shortest queue-based approaches for medical data distribution from edge to fog layers along with/without fail-over mechanisms in the cases of component failures at two levels of fog nodes and fog virtual machines (VMs). Different performability metrics of interest are analyzed including (i) recover token rate, (ii) mean response time, (iii) drop probability, (iv) throughput, (v) queue utilization of network devices and fog nodes to assimilate the impact of load-balancing techniques and fail-over mechanisms. Discrete-event simulation results highlight the effectiveness of the combination of these for enhancing the performability of medical services provided by an MIS. Particularly, performability metrics of medical service continuity and quality are improved with fail-over mechanisms in the MIS while load balancing techniques help to enhance system performance metrics. The implementation of both load balancing techniques along with fail-over mechanisms provide better performability metrics compared to the separate cases. The harmony of the integrated strategies eventually provides the trustworthiness of medical services at a high level of performability. This study can help improve the design of MIS systems integrated with different load-balancing techniques and fail-over mechanisms to maintain continuous performance under the availability constraints of medical services with heavy computing workloads in local hospitals/medical centers, to combat with new waves of virus pandemics.

Performance evaluation of mobile applications has received considerable attention as a prominent activity for improving services quality. Because many data stored on mobile device are synchronized with distributed data centers, the system availability is a critical attribute that requires investigation. Mobile backend‐as‐a‐service (MBaaS) allows developers to link the backend of their applications to cloud storage, as well as providing device management and integration with social networking services. The OpenMobster platform offers a complete synchronization service for mobile applications, but its availability is an inherent critical issue, because one failure can result in losses for companies that use this environment. Analytical models can be used to assess availability of this type of environment and perhaps mitigate downtimes. This paper proposes a hierarchical model to assess the availability of the MBaaS OpenMobster platform focusing on two scenarios: the basic architecture and the automatic recovery process. The designed models were validated through testbed measurements by automatically injecting and repairing the infrastructure. Taking into account the three layers: hardware, operating system, and the MBaaS OpenMobster, we observed OpenMobster being the most critical service component. We have applied failover strategy on the Java virtual machine, and we obtained 10% of reduction in annual downtime. This work may guide systems' administrators in planning their maintenance policies. Copyright © 2015 John Wiley & Sons, Ltd.