The Internet of Things (IoT) has influenced technology in numerous ways. What started as a network of physical devices communicating over the Internet grew tremendously sophisticated by incorporating billions of devices and defining specific IoT domains. IoT has found its subdomains in many fields such as medicine, healthcare, robotics, etc., and several domains are yet to incorporate IoT. One of the rapidly advancing technologies in space research. Space research has been growing tremendously over the last few decades, with studies ranging across exoplanet detection, colonization, space communication, and the possibility of life forms across other bodies. In this paper, we suggest a novel architecture of the Internet of Space Things (IoST) compatible with the cloud for the increasingly growing and futuristic field of space technology. The article proposes a detailed physical and logical architecture considering the public network, cloud provider, enterprise network, ground station, and interspace communication. The study will benefit researchers and scientists working in IoT, space technologies, colonization, robot-assisted surgery, space farming, etc.INDEX TERMS Internet of Things (IoT), Internet of Space Things (IoST), space technology, interspace communication, satellite network.ISHAANI PRIYADARSHINI received the M.S. degree in cybersecurity and the Ph.D. degree in artificial intelligence from the University of Delaware, USA. She is currently working as a Faculty with the School of Information, University of California at Berkeley. She has authored and edited several books for reputed publishers and is also the author to several publications for SCIE indexed journals. Her research interests include cybersecurity, artificial intelligence, and machine learning. As a certified reviewer, she conducts peer review of research papers for prestigious IEEE, Elsevier, and Springer journals, and is a part of the editorial board for many international journals.