Children who develop first episode psychosis during adolescence differ from children with normal development. The premorbid internalizing state is common to AG but social competencies and school problems are the most affected areas in EOS when compared to the AG. It is hypothesized that both EOS and AG can be considered as the expression of a previous vulnerability.

In these severely impaired children with PDDs, aripiprazole monotherapy was associated with a significant improvement in maladaptive behaviours in one-third of patients. Agitation and insomnia were the most frequent adverse effects. Further controlled studies in larger samples to explore possible predictors of efficacy are warranted.

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The objective was to describe the premorbid state of migraine with juvenile onset. Thirty subjects with migraine and 30 healthy subjects were enrolled in a case-control study. A structured questionnaire (Child Behavior Checklist, CBCL) was administered to the mothers and ratings were obtained for the past two age periods (0-3 and 4-6 years) and for the present state. CBCL scores of the migraine group (MG) were compared to those of the control group (CG) during the three periods. A longitudinal study was performed to evaluate the evolution of psychopathology comparing CBCL scores of MG in the three age periods. During the premorbid period MG showed significantly higher mean scores on total, internalising, anxious-depressive scales. In the longitudinal perspective, internalising traits were present in the premorbid period in MG. Children later diagnosed as having migraine differ from CG in several scales during different age periods. Migraine could be considered as the expression of a previous vulnerability.

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ResumenObjetivoDescribir el estado premórbido de la esquizofrenia de inicio temprano (EIT).MétodosSe comparó a 23 adolescentes con EIT con un grupo de control sano (GC) y con un grupo de pacientes anoréxicos (GA). El estado premorbido se estudió por medio de la CBCL y los datos obtenidos se analizaron utilizando ANOVA y la prueba de la t.ResultadosDurante el periodo premórbido, la EIT mostró puntuaciones significativamente más altas en todas las escalas en relación con el GC y sólo en algunas (social, problemas de pensamiento y atención, y competencias escolares) en relación con el GA.ConclusionesLos niños que desarrollan psicosis de primer episodio durante la adolescencia difieren de los niños con desarrollo normal. El estado internalizador premórbido es común al GA, pero las competencias sociales y los problemas escolares son las áreas más afectadas en la EIT cuando se compara el GA. Se plantea la hipótesis de que tanto la EIT como el GA se pueden considerar como la expresión de una vulnerabilidad previa.