To cite this version:Julie Vallée, Emmanuelle Cadot, Francesca Grillo, Isabelle Parizot, Pierre Chauvin. The combined effects of activity space and neighbourhood of residence on participation in preventive health-care activities: The case of cervical screening in the Paris metropolitan area (France).. Health Place, Elsevier, 2010, 16 (5) AbstractEstimates from multilevel regression of 1768 women living in the Paris metropolitan area showed that women who reported concentrating their daily activities in their perceived neighbourhood of residence had a statistically greater likelihood of not having undergone cervical screening during the previous two years. Furthermore, the characteristics of the administrative neighbourhood of residence (such as the practitioner density or the proportion of residents with a recent preventive consultation) had a statistically greater impact in terms of delayed cervical screening on women who concentrated the vast majority of their daily activities within their perceived neighbourhood of residence than among those who did not.The residential environment might promote or damage, to a greater extent, the health behaviour of people whose daily activities are concentrated within their perceived neighbourhood, since we can assume that their exposure to their neighbourhood characteristics is stronger.It could thus be useful to study more often the combined effects of activity space and neighbourhood of residence on participation in preventive health-care activities.Keywords activity space; daily mobility; neighbourhood of residence; cross-level interaction; preventive health care.2

BackgroundFood insecurity (FI) is the situation where people do not have, at all times, access to sufficient, safe and nutritious food that meets their dietary needs for an active and healthy life. The objectives of this study were to estimate the prevalence of FI in the Paris area by using, for the first time in France, a specific FI questionnaire and to identify the characteristics of food-insecure households, taking into account a potential neighbourhood effect.MethodsThis study is based on data from the third wave of the SIRS cohort study (a representative, population-based socioepidemiological study) that were analysed using a cross-sectional design. In 2010, 3000 individuals in the Paris metropolitan area (PMA) were interviewed. FI was investigated by means of the USDA’s HFSSM. We used stratified multilevel models across three household income categories to identify populations at risk for FI.ResultsIn 2010, 6.30% (95% CI = [4.99-7.97]) of the households in the PMA experienced FI (up to 13.59% in the most underprivileged neighbourhoods). About 2.50% of the households experienced severe FI and 2.85% of household living with an income above 1666 € experienced food insecurity, whereas the percentage raises to 23.38% among those living below the poverty threshold (<791 €). Depending on the income level, different household characteristics emerged as being associated with FI. In the poorest households, the presence of a child under 3 years of age was associated with an increased risk of FI (OR = 2.11; p = 0.03). Among higher-income households, the household composition appeared to be strongly associated with FI.ConclusionFI exists in several social groups in France. Its prevalence in the most underprivileged households should be considered an indicator of vulnerability, which could permit targeted social assistance policies.

No abstract

School food supplementation is a moderating factor in the association between household food insecurity and scholastic difficulties for adolescents.

ObjectivesThis study aims to compare breast cancer screening (BCS) and cervical cancer screening (CCS) practices of French women born to French parents with those of immigrants and nationals born to immigrants, taking their socioeconomic status into account.MethodsThe study is based on data collected in 2010 in the Paris metropolitan area among a representative sample of 3000 French-speaking adults. For women with no history of breast or cervical cancer, multivariate logistic regressions and structural equation models were used to investigate the factors associated with never having undergone BCS or CCS.ResultsWe confirmed the existence of a strong gradient, with respect to migration origin, for delaying or never having undergone BCS or CCS. Thus, being a foreign immigrant or being French of immigrant parentage were risk factors for delayed and no lifetime screening. Interestingly, we found that this gradient persisted (at least partially) after adjusting for the women’s socioeconomic characteristics. Only the level of income seemed to play a mediating role, but only partially. We observed differences between BCS and CCS which suggest that organized CCS could be effective in reducing socioeconomic and/or ethnic inequities.ConclusionSocioeconomic status partially explained the screening nonparticipation on the part of French women of immigrant origin and foreign immigrants. This was more so the case with CCS than with BCS, which suggests that organized prevention programs might reduce social inequalities.

Early T-cell Precursor ALL (ETP-ALL) is a subgroup of acute T leukemias with a peculiar immunophenotypic profile. Patients display a poor early response to conventional induction treatment, but an outcome after intensified therapy not worse than the other T-ALL. ETP-ALL was extensively characterized from a genetic point of view in the paper published by Zhang et al in 2012, but information about proteomic aberrancies is still lacking. In this study we profiled, by Reverse Phase Protein Arrays, the activation and expression of a considerable number of proteins in a significative cohort of 16 pediatric patients affected by ETP-ALL at diagnosis. We compared protein activation in these patients versus a group of 62 other T-ALL pediatric patients. Phosphoprotemic data were also related to mutational status of ETP-ALL patients. Our most interesting findings concern the hyperactivation of the LCK/Calcineurin and mTOR/STAT3 signaling pathways in ETP-ALL patients. LCK, despite of a lower expression, resulted strikingly boosted in these patients with a concomitant overexpression of the downstream target Calcineurin. The LCK/Calcineurin axis, followed by the activation of the NFAT family of transcription factors, was already demonstrated to be critical for T cell leukemogenesis. We also observed a possible feedback loop which could sustain mTOR activation through p70 S6Kinase hyperphosphorylation. mTOR, in turn, phosphorylates and activates STAT3, counteracting cell differentiation. The mTOR/STAT3 axis activity thus could sustain cell proliferation and survival while maintaining the markedly undifferentiated phenotype typical of ETP-ALL. Interestingly, the activation of the mTOR/STAT3 pathways is not influenced by the presence of FLT3 or PTEN mutations. Our paper also reports in ETP-ALL patients the hyperactivation of the RAS/MAPK and the JAK/STAT signaling pathways, that is not dependant from BRAF, NRAS, IL7R, JAK1 or JAK3 somatic mutations.\ud In conclusion, our study is the first one investigating the activation of a such number of proteins in a wide cohort of pediatric ETP-ALL patients. We identified the specific activation of signaling pathways, such as the LCK/Calcineurin and the mTOR/STAT3 ones, important for T cell leukemogenesis and for the support of cancer cell viability and block of differentiation. Our results will help to explain the mechanism responsible of the poor response to conventional treatment of these patients, and might also suggest new druggable targets for personalized and less toxic therapies

BackgroundFor the first time in France in a population-based survey, this study sought to investigate the potential impact of migration origin and the proportion of lifetime spent in mainland France on body mass index (BMI) and overweight in adults living in the Paris metropolitan area.MethodsA representative, population-based, random sample of the adult, French speaking population of the Paris metropolitan area was interviewed in 2005. Self-reported BMI (BMI = weight/height2) and overweight (BMI ≥ 25) were our 2 outcomes of interest. Two variables were constructed to estimate individuals’ migration origin: parental nationality and the proportion of lifetime spent in mainland France, as declared by the participants. We performed multilevel regression models among different gender and age groups, adjusted for demographics and socioeconomic status.ResultsIn women, a parental origin in the Middle East or North Africa (MENA) was associated with a higher risk of being overweight (especially before the age of 55) and a higher BMI (between 35 and 54 years of age), and so were women of Sub-Sahara African parental origin in the middle age category. Only in the youngest men (< 35 years of age) did we observe any association with parental nationality, with a higher BMI when having a MENA parentage. Regarding the association between the proportion of lifetime spent in France and overweight, we observed that, in women, a proportion of 50% to 99% appeared to be associated with overweight, especially after the age of 35. In men, having spent more than half of one’s lifetime in France was associated with a higher risk of overweight among oldest men.ConclusionsOur results plea for potential cultural determinants of overweight in the migrant and migrants-born populations in the French context of the capital region. Taking into account the people’ family and personal migration histories may be an important issue in public health research and policies on overweight and obesity prevention.

We examined the estrogen receptor measurement in 265 human breast cancer cytosols by using a specific method based on [3H]tamoxifen aziridine labeling, sequential immunoadsorption with an antiestrogen receptor monoclonal antibody (H-222), sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and autoradiography. These new tools of molecular endocrinology revealed an impressive estrogen receptor molecular polymorphism. Given the recent finding of a similar estrogen receptor polymorphism at the messenger RNA level by several laboratories, it is tempting to speculate about its possible biological significance. To gain insight into the potential clinical relevance of this polymorphism in terms of breast cancer hormone dependence, we compared the 265 cytosols for their [3H]tamoxifen aziridine- and [3H]estradiol-binding capacities using the above-mentioned method and the conventional dextran-coated charcoal assay. We failed to identify a specific [3H]tamoxifen aziridine electrophoretic pattern with respect to the tumor estrogen receptor content as measured by the dextran-coated charcoal assay. However, an excellent correlation overall was found between the intensities of both labeling methods. Some tumors were positive for only one of these two ligands. It will be clinically important to see whether the tumors positive for [3H]tamoxifen aziridine only correspond to the small subset of tumors (10%) which respond to tamoxifen treatment despite very low estrogen receptor levels, as measured by the dextran-coated charcoal technique.