Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epidermal growth factor receptor kinase activities of 1,2,4-thiadiazole-1,2,4-triazole analogues thereby reducing human lung cancer. The software used to achieve this work were Spartan 14, Pymol, mgltools_win32_1.5.6, Auto dock vina and biovia2019.ds2019client. Also, the developed QSAR model was developed using the screened descriptors so as to inspect the closeness between the experimental IC
50
and the predicted IC
50
. More so, the binding affinity from 1,2,4-thiadiazole-1,2,4-triazole derivatives - epidermal growth factor receptor kinase complexes using molecular docking approach were reported. Also, the ADMET properties for selected compounds and proposed compounds with better binding affinity were reported.
This paper examined the three-dimensional stretched flow, heat, and mass transports analysis of Prandtl fluid with the influences of chemical reactions, over a Riga surface. This analysis is investigated in presence of Catteneo-Cristov heat and mass fluxes. The resulting nonlinear models are simplified by appropriate similarity variables. The solutions of the reduced set of coupled equations are obtained numerically via the Chebyshev spectral collocation technique. The obtained numerical results were used to address and discuss the characteristics of flow, heat transfer, mass distribution, skin friction, Nusselt, and Sherwood numbers for various pertinent parameters. In addition, the validation of the present numerical scheme is achieved by comparing it with previous results obtained through other numerical results. It is noticed that the rate of heat and mass transfer escalate for the Prandtl parameter. Also, the thermal and mass distributions scale back with a high estimation of relaxation parameters.This paper examined the three-dimensional stretched flow, heat, and mass transports analysis of Prandtl fluid with the influences of chemical reactions, over a Riga surface. This analysis is investigated in presence of Catteneo-Cristov heat and mass fluxes. The resulting nonlinear models are simplified by appropriate similarity variables. The solutions of the reduced set of coupled equations are obtained numerically via the Chebyshev spectral collocation technique. The obtained numerical results were used to address and discuss the characteristics of flow, heat transfer, mass distribution, skin friction, Nusselt, and Sherwood numbers for various pertinent parameters. In addition, the validation of the present numerical scheme is achieved by comparing it with previous results obtained through other numerical results. It is noticed that the rate of heat and mass transfer escalate for the Prandtl parameter. Also, the thermal and mass distributions scale back with a high estimation of relaxation parameters.
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