A sepse representa um evento mórbido de extrema importância do ponto de vista clínico e de saúde pública, atingindo milhares de pessoas anualmente, no mundo. De uma perspectiva imunológica, os macrófagos são células extremamente importantes na interação Homo sapiens sapiens/ bactérias, ainda que muitos aspectos da atuação dessas células permaneçam aguardando elucidação. O presente artigo apresenta os requerimentos para a simulação computacional do macrófago no sistema AutoSimmune, permitindo o desenvolvimento de estudos sobre o papel dessa célula na sepse. Artificial macrophages and the human immune system computational modeling for the investigation of sepsis pathophysiology: Perspectives Abstract Sepsis represents a morbid event of fundamental importance both from clinical and public health point of view, affecting thousands of people worldwide annually. From the immunological perspective, macrophages are extremely important cells in the interaction Homo sapiens sapiens / bacteria. However, several aspects concerning the action of these cells await elucidation. This paper presents the requirements for computational simulation of macrophage in the AutoSimmune system, allowing the development of studies on the role of this cell in sepsis.
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