Degradation of two blood group substances possessing H and Le" activity by 0.05 N NaOH and 1.0 M NaBH4 gave a mixture of oligosaccharide chains all ending with N-acetyl-D-galactosaminitol with minimal amounts of degradation products. Passage of the dialyzable material on Bio-Gel P-2 revealed substantial heterogeneity evident primarily from the presence of several peaks and from the distribution of fucose. In the H active substance this sugar was present in several included peaks while it was restricted almost exclusively to the excluded carbohydrate fraction of the Le" active glycoprotein. Although the gel filtration profiles of T he series of oligosaccharides isolated in this and in other laboratories from blood group active glycoproteins by various degradation procedures such as mild acid hydrolysis and alkaline or alkaline borohydride degradation have been fundamental for establishing the structure of the blood group t
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