Immunochemical Studies on Blood Groups. XXXIV. Structures of Some Oligosaccharides Produced by Alkaline Degradation of Blood Group A, B, and H Substances<sup>*</sup>

Lloyd, Kenneth O.; Kabat, Elvin A.; Layug, Espriela J.; Gruezo, Flavio

doi:10.1021/bi00869a007

Cited by 174 publications

(91 citation statements)

References 29 publications

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“…7), is a relatively rare sequence in humans. It was first identified in ovarian cyst mucin (32), was subsequently found on a variety of different tumors (33), and is generally considered to be a cancer-associated antigen. However, it is significant that Lewis y is known to occur on normal glycoproteins in seminal plasma.…”

Section: Discussionmentioning

confidence: 99%

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Morris

Dell

Easton

et al. 1996

Journal of Biological Chemistry

141

136

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We have recently demonstrated that a human amniotic fluid-derived glycoprotein, glycodelin-A (GdA; previously known as PP14 or PAEP), potently inhibits gamete binding in an established sperm-egg binding system and expresses immunosuppressive activities directed against a variety of different immune cell types. GdA has high mannose-, hybrid-, and complex-type biantennary oligosaccharides including structures with fucosylated or sialylated N,N-diacetyllactosediamine (GalNAc␤1-4GlcNAc) sequences, which are rare in other human glycoproteins. We now report the characterization of glycodelin-S (GdS). This is a human seminal plasma glycoprotein that is immunologically indistinguishable from GdA, but unlike the latter, does not inhibit human sperm-zona pellucida binding under hemizona assay conditions. Analysis of the N-glycans of GdS by mass spectrometry revealed that all glycoforms of GdS are different from those of GdA. GdS glycans are unusually fucose-rich, and the major complex-type structures are biantennary glycans with Lewis x (Gal␤1-4(Fuc␣1-3)GlcNAc) and Lewis y (Fuc␣1-2Gal␤1-4 (Fuc␣1-3)GlcNAc) antennae. It is probable that these highly fucosylated epitopes contribute to the immunosuppressive activity of human seminal plasma and to the low immunogenicity of sperm. This study provides the first evidence for gender-specific glycosylation that may serve to regulate key processes involved in human reproduction.

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Section: Discussionmentioning

confidence: 99%

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Morris

Dell

Easton

et al. 1996

Journal of Biological Chemistry

141

136

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show abstract

“…,B-D-GNAc (1 -N)Asn andp-n-Gal All sugars except N-acetylneuraminic acid were determined by gas/liquid chromatography as their alditol acetates (19). Hexosamines were also determined colorimetrically (20)(21)(22). N-Acetylneuraminic acid was quantified according to Warren (23).…”

Section: Methodsmentioning

confidence: 99%

Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.

Hammarström

Engvall

Johansson

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition, it has been found that apoptosis accompanying elevation of intracellular calcium level occurs in the floating cells, but not in the (1), which was originally detected and characterized among a number of oligosaccharides released from ovarian cyst mucin blood group antigen by alkaline degradation (7,14), is useful phenotypic marker predictive of apoptosis (10). In addition, it has been shown that Ley expression in histological sections of kidney, gastric and oesophageal cancer are correlated with cellular differentiation and proliferation (10).…”

Section: Discussionmentioning

confidence: 99%

Induction of Differentiation and Apoptosis, and Ley Antigen Expression by Treatment with 3,4-Dihydro-6-(4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl)-2(1H)-Quinolinone (Vesnarinone) in a Human Salivary Cancer Cell Line.

Sato

Harada

Yoshida

1994

Acta Histochem. Cytochem

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Immunochemical Studies on Blood Groups. XXXIV. Structures of Some Oligosaccharides Produced by Alkaline Degradation of Blood Group A, B, and H Substances^*

Cited by 174 publications

References 29 publications

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.

Induction of Differentiation and Apoptosis, and Ley Antigen Expression by Treatment with 3,4-Dihydro-6-(4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl)-2(1H)-Quinolinone (Vesnarinone) in a Human Salivary Cancer Cell Line.

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Immunochemical Studies on Blood Groups. XXXIV. Structures of Some Oligosaccharides Produced by Alkaline Degradation of Blood Group A, B, and H Substances*

Cited by 174 publications

References 29 publications

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.

Induction of Differentiation and Apoptosis, and Ley Antigen Expression by Treatment with 3,4-Dihydro-6-(4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl)-2(1H)-Quinolinone (Vesnarinone) in a Human Salivary Cancer Cell Line.

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Immunochemical Studies on Blood Groups. XXXIV. Structures of Some Oligosaccharides Produced by Alkaline Degradation of Blood Group A, B, and H Substances^*