In this work, we have explored new stable structures of the Au32Z (Z = +1, 0, -1) clusters. Theoretical calculations using density functional theory within the generalized-gradient approximation were performed. Our results show that, in the anion state (Au32-), low-symmetry (disordered) structures are preferred over the caged fullerene-like isomer. In addition, the cationic cluster (Au32+) also exhibits a disordered low-symmetry structure as its lowest energy configuration, but it is much closer in energy to the fullerene-like isomer. These results, obtained at T = 0 K, indicate that disordered structures for the Au32- and Au32+ clusters may be detected not only at room temperature, as was experimentally verified for the Au32- one, but also at much lower temperatures.
We present 3D, adaptive mesh refinement simulations of G2, a cloud of gas moving in a highly eccentric orbit towards the galactic center. We assume that G2 originates from a stellar wind interacting with the environment of the Sgr A* black hole. The stellar wind forms a cometary bubble which becomes increasingly elongated as the star approaches periastron. A few months after periastron passage, streams of material begin to accrete on the central black hole with accretion rateṡ M ∼ 10 −8 M ⊙ yr −1 . Predicted Brγ emission maps and position-velocity diagrams show an elongated emission resembling recent observations of G2. A large increase in luminosity is predicted by the emission coming from the shocked wind region during periastron passage. The observations, showing a constant Brγ luminosity, remain puzzling, and are explained here assuming that the emission is dominated by the free-wind region. The observed Brγ luminosity (∼ 8 × 10 30 erg s −1 ) is reproduced by a model with a v w = 50 km s −1 wind velocity and a 10 −7 M ⊙ yr −1 mass loss rate if the emission comes from the shocked wind. A faster and less dense wind reproduces the Brγ luminosity if the emission comes from the inner, free wind region. The extended cometary wind bubble, largely destroyed by the tidal interaction with the black hole, reforms a few years after periastron passage. As a result, the Brγ emission is more compact after periastron passage.
Carbon nanotubes (CNTs) have emerged in recent years as a potential option for drug delivery, due to their high functionalization capacity. Biocompatibility and selectivity using tissue-specific biomolecules can optimize the specificity, pharmacokinetics and stability of the drug. In this study, we design, develop and characterize a drug nanovector (oxCNTs-HA-CPT) conjugating oxidated multi-wall carbon nanotubes (oxCNTs) with hyaluronate (HA) and carboplatin (CPT) as a treatment in a lung cancer model in vitro. Subsequently, we exposed TC–1 and NIH/3T3 cell lines to the nanovectors and measured cell uptake, cell viability, and oxidative stress induction. The characterization of oxCNTs-HA-CPT reveals that on their surface, they have HA. On the other hand, oxCNTs-HA-CPT were endocytosed in greater proportion by tumor cells than by fibroblasts, and likewise, the cytotoxic effect was significantly higher in tumor cells. These results show the therapeutic potential that nanovectors possess; however, future studies should be carried out to determine the death pathways involved, as well as their effect on in vivo models.
Background: Silica nanoparticles (nanoSiO 2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO 2 has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. Moreover, the precise mechanisms underlying this energetic debacle remain unclear. In order to elucidate these mechanisms, this article explores the ex vivo heart function and mitochondria after exposure to nanoSiO 2 .
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