Telang flower (Clitoria ternatea L.) is a plant that has antibacterial properties. The chemical content contained in it which is antibacterial is flavonoids, alkaloids, tannins, saponins and terpenoids. Staphylococcus epdiermidis is one of the bacteria that causes various infections including mild skin infections accompanied by abscess formation. This study aims to test the activity of the telang flower by maceration using 70% ethanol as a solvent. For antibacterial testing with the disk diffusion method. Extracts are made in various concentrations of 10%, 15%, 20%. The positive control used was Chloramphenicol. The results of this study were the average inhibition zone of the telang flower extract against Staphylococcus epidermidis bacteria was 2.31 mm at a concentration of 10%, 3.05 mm at a concentration of 15%, and 6.2 mm at a concentration of 20%. These results indicate that the telang flower extract has antibacterial activity against Staphylococcus epidermidis bacteria, although the inhibition produced is not strong. At a concentration of 20% telang flower extract had the greatest inhibition on the growth of Staphylococcus epidermidis bacteria than the concentrations of 10% and 15%.
Kombucha bunga telang merupakan minuman fermentasi probiotik yang diproduksi oleh konsorsium bakteri dan khamir. Bahan baku utama dalam pembuatan kombucha dalam penelitian ini adalah berupa rebusan bunga telang. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri kombucha bunga telang pada konsentrasi gula aren yang berbeda-beda. Konsentrasi gula aren yang berbeda-beda untuk digunakan dalam penelitian ini adalah 20%, 30%, dan 40% (b/v). Masing-masing perlakuan diulang sebanyak 3 kali. Kontrol positif yang digunakan dalam penelitian ini adalah kombucha yang berbahan dasar teh hijau, sedangkan kontrol negatif yang digunakan dalam penelitian ini adalah berupa akudes steril. Salah satu metode yang digunakan dalam pengujian antibakteri adalah difusi cakram dengan cara menghitung diameter zona hambat. Fermentasi kombucha bunga telang mempunyai antibakteri pada spektrum sempit. Hal tersebut diindikasikan oleh daya hambatnya terhadap pertumbuhan Salmonella thypi, dan Vibrio parahaemolyticus. Kombucha bunga telang pada konsentrasi gula aren sebesar 40% menunjukkan aktivitas antibakteri terbaik, sehingga konsentrasi gula aren tersebut sebagai substrat pada fermentasi kombucha bunga telang berpotensi untuk dimanfaatkan sebagai inovasi minuman fungsional produk bioteknologi terkini dalam menunjang peningkatan sistem imun.
Kombucha which is efficacious as a source of antioxidants, antibacterial, and anticancer, and alcohol content below 1% deserves to be developed as a raw material for halal drugs and cosmetics in the perspective of biotechnology that underlies the bioinformatics side and gene expression as the initial topic in designing it. The purpose of this review study is to further ensure the feasibility of kombucha as a raw material for halal cosmetics from various supporting scientific findings. The results of the study show that the potential of kombucha as a source of antioxidants, antibacterial, and anticancer agents requires further modification as an opening to prove that it is halal in silico, in vitro, and in vivo from a biotechnology perspective. The development of kombucha as a raw material for halal-standard medicines and cosmetics requires serious research collaboration from biotechnologists engaged in medicine, pharmacy, agriculture, nutrition science, and food technology.
Kombucha has an anticancer potency because it has dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate compound. The research aimed to verify the compound dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate as an anticancer with the in-silico method, namely the molecular docking approach, drug likeness profile, and ADMET test. The tools used were the PyRx, Discovery Studio Visualizer, Sanjeevini, and pkCSM. The research material consisted of 3D Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate and Epidermal Growth Factor Receptor (EGFR). The analysis showed Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate is safe for consumption and can suppress cancer cells.
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