Background The aim of this study was to determine the frequency of hypoalbuminemia and in-hospital mortality in acute ischemic stroke patients at a tertiary care hospital in Hyderabad. Methodology This was a prospective observational study conducted at the Department of Medicine, Isra University Hospital, Hyderabad, from February 17, 2017 to August 18, 2017. A total of 196 consecutive cases of acute ischemic stroke were included. Hypoalbuminemia was defined as serum albumin of <3.5 mg/dL. In-hospital outcome in terms of survival or death within seven days of admission was assessed and recorded. Data were analyzed using SPSS, version 20.0. (IBM Corp., Armonk, NY, US). Chi-square test was applied, and p-value of ≤0.05 was considered significant. Results Out of the 196 acute ischemic stroke cases, 146 (74.5%) were males and 50 (25.5%) were females. The mean age was 49.31 ± 10.46 years. A total of 90 (45.9%) cases had hypoalbuminemia. Out of these 196 cases, 22 (11.2%) expired within seven days of presentation of acute ischemic stroke, and out of these 22 expired cases, 18 (81.8%) had hypoalbuminemia. In-hospital mortality was found to be strongly associated with hypoalbuminemia (p < 0.001). Conclusions Frequency of hypoalbuminemia was significantly higher in ischemic stroke patients and was found to be associated with in-hospital mortality, warranting monitoring at regular intervals, as well as recognizing and treating it early for risk stratification.
ABSTRACT… Objectives:To assess the diagnostic validity of FIB-4 for predicting hepatic fibrosis in patients of chronic hepatitis C genotype 3. Study Design: Cross-sectional study. Setting: Department of Gastroenterology and Hepatology, Isra University Hospital, Hyderabad through convenient sampling. Period: June 2013 to June 2014. Methods: Diagnostic validity of FIB-4 index for predicting hepatic fibrosis was determined by measuring sensitivity, specificity, positive productive, negative predictive value, and compared these parameters with liver biopsy. The liver histology was determined by METAVIR score. Results: A total 115 patients were enrolled with mean and SD of age was 39.6 ± 9.3 years. Dividing FIB-4 index into three categories as <1.45, 1.45 -3.25, and >3.25; by using the Obuchowski method the AUROC was 0.93 (with 95% CI 0.91, 0.95). When dividing the FIB-4 index in to three categories as <1.45, 1.45 -<2.25 and >2.25; the AUROC by using Obuchowski method was 0.87 (with 95% CI 0.83, 0.91). Similarly for the diagnosis of Cirrhosis (F = 4 METAVIR) on the predictive value of the non-invasive test FIB-4 while using Obuchowski method the AUROC was 0.85 (with 95% CI 0.83, 0.87). Conclusion: The FIB-4 index is a simple, inexpensive, non-invasive, and a quick test for predicting liver fibrosis in patients of chronic Hepatitis C genotype 3. Key words:Liver biopsy, Metavir, Non-invasive, Cirrhosis, Fibrosis, Pakistan.
Objectives: To assess the diagnostic validity of FIB-4 for predicting hepaticfibrosis in patients of chronic hepatitis C genotype 3. Study Design: Cross-sectional study.Setting: Department of Gastroenterology and Hepatology, Isra University Hospital, Hyderabadthrough convenient sampling. Period: June 2013 to June 2014. Methods: Diagnostic validity ofFIB-4 index for predicting hepatic fibrosis was determined by measuring sensitivity, specificity,positive productive, negative predictive value, and compared these parameters with liverbiopsy. The liver histology was determined by METAVIR score. Results: A total 115 patientswere enrolled with mean and SD of age was 39.6 ± 9.3 years. Dividing FIB-4 index into threecategories as <1.45, 1.45 - 3.25, and >3.25; by using the Obuchowski method the AUROC was0.93 (with 95% CI 0.91, 0.95). When dividing the FIB-4 index in to three categories as <1.45,1.45 - <2.25 and >2.25; the AUROC by using Obuchowski method was 0.87 (with 95% CI 0.83,0.91). Similarly for the diagnosis of Cirrhosis (F = 4 METAVIR) on the predictive value of thenon-invasive test FIB-4 while using Obuchowski method the AUROC was 0.85 (with 95% CI0.83, 0.87). Conclusion: The FIB-4 index is a simple, inexpensive, non-invasive, and a quicktest for predicting liver fibrosis in patients of chronic Hepatitis C genotype 3.
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