About 100 million women are estimated to be circumcised globally. Various rates of complications have been encountered, especially after circumcision, such as bleeding, infection, shock, menstrual irregularity, difficulty in urination or common urinary tract infections, inguinal pain, difficulty in sexual intercourse, and genital circumcision scar especially at the vulvar region, and cystic or solid character mass in short and long term. Furthermore, the maternal-fetal morbidity and mortality increase due to bleeding and fistula, which develop after prolonged labor, travail, and difficult labors. Our aim in this paper was to discuss a 42-year-old multiparous female case who had undergone type 2 radical genital mutilation (circumcision) when she was 7 years of age, along with the literature, which has been evaluated for the gradually growing mass at the left inguinal canal region in the last 10 years and diagnosed as epidermoid inclusion cyst developing secondary to postcircumcision surgical ground trauma, since there was no other case found in the literature search that had been circumcised at such an early age and developing after circumcision at such advanced age, and, therefore, this is suggested to be the first case on this subject.
Castleman's disease (CD) is described as a nodal lympho-follicular hyperplasia and mostly seen in thoracic cavity. The occurrence in pelvic cavity is very rare. It is usually mimicking the pelvic adnexal solid-heterogenous tumoral mass. So the preoperative diagnosis is mostly difficult. We now present a case of pe lvic CD in a woman who complaint from pelvic pain. The patient underwent laparotomy with suspicious of adnexal tumor. However, the diagnosis was made at histopathologic examination postoperatively. The surgery was curative in this case and no recu rrence was observed in the patient.
DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a rare type of delayed drug hypersensitivity reaction characterised by fever, skin rash, lymphadenopathy, and visceral involvement, which can be life threatening and is a childhood event. An eight-year-old boy was admitted with complaints of extensive rash and fever three weeks after the onset of treatment with carbamazepine for a diagnosis of epilepsy. Fever, as well as patches and plaques with indeterminate limits that tended to merge and were non-blanchable on a widespread erythematous layer, were revealed in physical examination. Extensive cervical, submandibular, and inguinal lymphadenopathy was observed. We present ours as the second case of myocarditis secondary to DRESS syndrome after carbamazepine use in the literature.
Tel: 0 532 302 91 11 (J Curr Pathol. 2017;3:53-9.) ÖZET Amaç: serviks kanseri, önleme programlarına rağmen dünya genelinde kadın ölümlerinin önde gelen nedenlerindendir. bu çalışmanın amacı, servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom olgularında, HPV-HR ve p16 değerlendirilmesi ile sitolojik ve histopatolojik sonuçların karşılaştırılmasıdır. Gereç ve Yöntem:Hastanemiz Patoloji Kliniğinde histopatolojik olarak servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom tanısı almış 51 olgu daha önceki servikal smear sonuçları ile uyumluluk açısından değerlendirildi. silver in situ hibridizasyon yöntemi ile servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom olgularında HPV-HR varlığı ve aynı doku biyopsilerinde immünohistokimyasal olarak p16 ekspresyonu değerlendirildi. Bulgular: smear sonuçlarına göre servikal intraepitelyal neoplazi düzeyinin farklılık gösterdiği saptandı. Mevcut bulgulardan smearlerinde yüksek dereceli skuamöz intraepitelyal lezyon ile ayrılamayan atipik skuamöz hücreler ve yüksek dereceli skuamöz intraepitelyal lezyon saptanmış olan olguların, doku biyopsilerinde CIn I'e nazaran daha çok CIn II ve CIn III tanısı aldıkları saptanmıştır. Aynı test ile değerlendirildiğinde HPV-HR düzeyine göre histolojik tanı tiplerinin farklılık gösterdiği saptandı. Histopatolojik incelemede CIn I olarak değerlendirilen olguların %35'inde, CIn II olarak değerlendirilen olguların %93.3'ünde, CIn III olarak değerlendirilen olguların %92.3'ünde ve skuamöz hücreli karsinom olarak değerlendirilen olguların %100'ünde p16 ile pozitif boyanma görülmüştür.Sonuç: servikal smear testi, in situ hibridizasyon yöntemi ile HPV-HR değerlendirilmesi ve immünohistokimyasal olarak p16 uygulanması, servikal intraepitelyal neoplazilerin erken tanı ve tedavisinde oldukça önemli ve gereklidir.Anahtar Sözcükler: serviks, sitoloji, Histopatoloji, HPV-HR, p16 ABSTRACT Aim: Cervical carcinoma is still one of the leading causes of mortality in women worldwide despite the preventing programmes. The aim of this study is to evaluate the comparison of results of the cytology and histopathology in cervical intraepithelial neoplasia and squamous cell carcinoma cases and to confirm the presence of HPV-HR and p16. materials and methods: We evaluated fifty one cases of cervical intraepithelial neoplasia and squamous cell carcinoma cases with their cytology results. HPV-HR was assesed by silver insitu hybridization and p16 immunohistochemical expressions in cervical intraepithelial neoplasia and squamous cell carcinoma cases. Results:The level of CIn showed a significant difference for cytological results. Cases with a cytological diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion had more CIn II and CIn III diagnosis in their histological materials. Histopathological types showed statistically significant difference for HR-HPV levels. p16 positive staining was detected in 35% of CIn I, 93.3% of CIn II, 92.9% of CIn III, and 10...
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