Evaluation of hpv and p16 expression in the cervical intraepithelial neoplasia

Kimiloglu, Elife; Gündoğar, Özgecan; Demir, Feyza; Ozcan, Zuhal; Cin, Merve; Erdoğan, Nusret

doi:10.5146/jcpath.2017.12

Cited by 1 publication

(2 citation statements)

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“…It has been shown that the number of atypical smear diagnoses increase when using TIS ( 5 , 6 ). In studies that compared the TPMM and the TPAM, similar results for ASCUS, LSIL and HSIL diagnoses were noted ( 7–9 ).…”

Section: Discussionmentioning

confidence: 99%

“…This technique is more expensive than the classical Pap smear test; however, since it is a more sensitive test, the requirement of longer between-screening intervals balances its higher cost. Liquid-based cytology can decrease the rate of false negative results arising from errors made during screening tests and from interpretation of cytological test results ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the diagnostic utility of manual screening and the thinprep imaging system in liquid-based cervical cytology

Özcan

Kimiloglu²,

Igdem³

et al. 2019

TJPATH

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Objective: To compare the diagnostic results of the ThinPrep manual method (TPMM) and ThinPrep automated method (TPAM) in liquid-based cytology and present the advantages and disadvantages of both methods. Material and Method: A total of 1.500 randomized ThinPrep Pap tests that were screened manually and archived in 2015 were reviewed by a blinded researcher manually and by the ThinPrep automatic method. Results: There was a 83.3% increase in the detection of ASCUS (Atypical squamous cells of undetermined significance) with the TPAM compared to the TPMM, and with respect to the reference results, the accuracy was higher for the TPAM than for the TPMM. We also noted a 33.3% increase in the rate of LSIL (Low grade squamous intraepithelial lesion) and 20% increase in the rate of HSIL (High grade squamous intraepithelial lesion) by the TPAM. Concordance was best between the TPAM and reference cytologic diagnoses. The sensitivity was higher for the TPAM and the specificity was similar for both methods. The false positive rate was higher for the TPAM than the TPMM but the false negative rate was higher for the TPMM. We determined a 30% gain in screening time per smear by the TPAM. However, rejection of many samples by the system, especially because of air bubbles, was a limitation of the TPAM. Conclusion: The TPAM has advantages over the TPMM as well as disadvantages such as limiting features and a high false positive rate. The TPAM should be supported by the manual method to decrease the false positive rate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%