Biochemical syntheses
Biochemical syntheses O 0035Highly Stereoselective Reduction of Haloketones Using Three New Yeasts: Application to the Synthesis of (S)-Adrenergic β-Blockers Related to Propranolol. -By application of whole resting cells of the new strains for the reduction of chloroketones (I) and (III) best conversions and enantioselectivities are observed compared to cells of S. cerevisiae. The use of these microorganism is an efficient alternative to the resolution of halohydrins employing lipases. -(MARTINEZ LAGOS, F.; CARBALLEIRA, J. D.; BERMUDEZ, J. L.; ALVAREZ, E.; SINISTERRA*, J. V.; Tetrahedron: Asymmetry 15 (
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