A new synthesis of porphyrins from pyrrole and substituted benzaldehydes, is described, using high-valent transition metal salts [VOCl,, VO(OEt)C12, VO(OPr')C12, TiC14 and Mn(OAc),] as aromatizing agents. This process allows higher working concentrations and larger amounts of reagent to be used, than those previously described.
Dihalogenocarbenes generated using low-valent titanium (LVT) undergo a one-pot cycloaddition to diaryl, aryl alkyl or dialkyl ketones to give m,a-disubstituted acetic acids such as (R,S)-2-arylpropanoic acids. TiI, proved most effective in this reaction for which the product yield was optimized by use of an excess of reducing agent.Paper 5/0 1200G
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