The objective this work was to evaluate specific economic data of the production of yellow passion fruit under influence of different doses of NPK, in the form of N, P2O5 and K2O, in an area with incidence of virose in the city of Presidente Prudente, State of São Paulo. The following doses of NPK were evaluated: N (150 to 1200 kg ha-1), P2O5 (200 to 1600 kg ha-1) and K2O (100 to 700 kg ha-1). Miyake et al. (2016) describe the methodology used in the formation of seedlings, fertilization and cultural treatments of passion fruit. The data used in the economic analysis were: productivity, commercial production, percentage and fruits of each commercial classification, cost of production and profitability of passion fruit. At the economical part, structures of the COE and TOC and four indicators of profitability were used. It was observed percentage difference in the operational cost of production of 4.0% between the highest and the lowest dose of N, of 5.8% among doses of P2O5 and 1.7% among doses of K2O. The total operating cost ranged from $29,119.77 to $31,113.09 per hectare. The profitability indicators were not favorable. It was concluded that the region of Presidente Prudente-SP, in areas with an incidence of viral infection, it is not recommended the plantation of passion fruits. However, at times with high selling price of fruit (average above R$ 1.95 kg-1), the dose of NPK indicated refers to 300 kg of N, 400 kg of P2O5 and 500 kg of K2O ha-1.