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O Staphylococcus aureus faz parte da microbiota natural, principalmente da pele, podendo tornar-se patogênico em condições como a quebra da barreira cutânea ou diminuição da imunidade. Os traumas que comprometem a integridade da barreira cutânea constituem-se na principal causa de mudança de comportamento deste microrganismo, para o agente etiológico mais comum de infecções cutâneas 1 2 6 .As infecções mais comuns envolvem a pele (celulite, impetigo) e feridas em sítios diversos. Algumas infecções por Staphylococcus aureus são agudas, piogênicas e podem disseminar para diferentes tecidos e provocar focos metastáticos. Episódios mais graves, como bacteremia, pneumonia, osteomielite, endocardite, ABSTRACTMethicillin-resistant Staphylococcus aureus was initially described as a typical microorganism acquired in nosocomial infections. However, over recent years, community-acquired methicillin-resistant Staphylococcus aureus has been a cause of skin and soft-tissue infections. Serious infections such as pneumonia and sepsis can also occur. This report describes a case of sepsis in a child that was complicated by pneumonia secondary to soft tissue lesions that were due to community-acquired methicillin-resistant Staphylococcus aureus in southern Brazil. The patient was attended at the Emergency Unit with a history of injury caused by lower-limb trauma that evolved to cellulitis, pneumonia and sepsis. Tradicionalmente, as infecções causadas por este patógeno estavam limitadas aos hospitais, porém, a partir da década passada, infecções foram descritas em todo o mundo, de forma

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Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent. The patient developed septic shock, multiple organ failure and died on day 50 post-transplantation. Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered.