Dermatofibrosarcoma protuberans (DFSP) of the breast is a rare malignant tumor, and its preoperative diagnosis is extremely difficult. Local recurrence of DFSP is frequent after incomplete resection because of either false diagnosis or inadequate standard surgical excision. We present a case of DFSP that showed disconcordant results using different imaging modalities, suggesting that the MRI finding of subcutaneously located highly vascular tumor with suspicious kinetics but together with negative Cho peak on (1H) MRS, might be suggestive of the diagnosis of DFSP.
Background: This study aimed to examine the incidence of surgical complications associated with nipple-sparing mastectomy (NSM) with primary implant reconstruction, analyze risk factors for early and late surgical complications of NSM, and determine the incidence of local recurrences and the safety of sparing the nipple-areola complex (NAC). Methods: This retrospective cohort study included 435 patients with 441 NSM procedures over a period of 9 years (2004-2012). All surgical complications and the oncological outcome were recorded during follow-up. Results: The most common early surgical complication was skin flap ischemia/necrosis (26 patients, 5.9%). Prosthesis explantation due to complications was carried out in 11 (2.5%) cases. Neoadjuvant chemotherapy, implant size >500 ml, diabetes mellitus, body mass index > 25 kg/m2, and incisions other than lateral were risk factors for early complications (p < 0.001). The NAC excision rate was 5.4% (24 cases) due to confirmed presence of cancer cells in the subareolar tissue. Capsular contracture as a late complication occurred in 33 (7.48%) cases. Local relapse occurred in 32 (7.3%) patients. Distant metastases were diagnosed in 68 (15.6%) patients, and 53 (12.2%) patients died during the follow-up period. Conclusions: NSM with immediate implant reconstruction has an acceptable morbidity rate and is an oncologically and surgically appropriate treatment for most women requiring mastectomy.
This text is based on the recommendations accepted by the 4th Hungarian Consensus Conference on Breast Cancer, modified on the basis of the international consultation and conference within the frames of the Central-Eastern European Academy of Oncology. The recommendations cover non-operative, intraoperative and postoperative diagnostics, determination of prognostic and predictive markers and the content of cytology and histology reports. Furthermore, they address some specific issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement, and some remarks about the future.
Background: Benefits from the neoadjuvant approach are survival benefits and
breast conservation surgery rather than mastectomy. The purpose of our study
was to evaluate the incidence and risk factors that influence early local
complications in patients that had breast surgery after neoadjuvant
polychemotherapy. Methods: This retrospective study was undertaken with 361
breast cancer patients (women) who were treated at the Oncology Institute of
Vojvodina from January 2007 to December 2012. In the first group (N1=103)
were the patients who underwent neoadjuvant polychemotherapy and in the
second group (N2=258) were patients who did not take neoadjuvant
polychemotherapy. Surgery procedures were breast conservative surgery,
mastectomy, or nipple sparing mastectomy with immediate breast
reconstruction, depending on tumor stage after polychemotherapy. Median
follow-up of patients after operation was 49 months (ranging from 15 to 75
months). Results: The average reduction of tumor volume after neoadjuvant
polychemotherapy was 30%. Most common complications were prolonged seroma
formation and minor skin necrosis. Obesity, older age, smoking, and diabetes
mellitus were recognized as risk factors for early postoperative
complications after neoadjuvant polychemotherapy (p<0.05). Conclusion:
Obesity, older age, smoking, and diabetes mellitus were recognized as risk
factors for early postoperative complications after neoadjuvant
polychemotherapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.