Background: Benefits from the neoadjuvant approach are survival benefits and
breast conservation surgery rather than mastectomy. The purpose of our study
was to evaluate the incidence and risk factors that influence early local
complications in patients that had breast surgery after neoadjuvant
polychemotherapy. Methods: This retrospective study was undertaken with 361
breast cancer patients (women) who were treated at the Oncology Institute of
Vojvodina from January 2007 to December 2012. In the first group (N1=103)
were the patients who underwent neoadjuvant polychemotherapy and in the
second group (N2=258) were patients who did not take neoadjuvant
polychemotherapy. Surgery procedures were breast conservative surgery,
mastectomy, or nipple sparing mastectomy with immediate breast
reconstruction, depending on tumor stage after polychemotherapy. Median
follow-up of patients after operation was 49 months (ranging from 15 to 75
months). Results: The average reduction of tumor volume after neoadjuvant
polychemotherapy was 30%. Most common complications were prolonged seroma
formation and minor skin necrosis. Obesity, older age, smoking, and diabetes
mellitus were recognized as risk factors for early postoperative
complications after neoadjuvant polychemotherapy (p<0.05). Conclusion:
Obesity, older age, smoking, and diabetes mellitus were recognized as risk
factors for early postoperative complications after neoadjuvant
polychemotherapy.
Purpose: Purpose of this study was to evaluate early complications and risk factors associated with nipple sparing mastectomy and immediate breast reconstruction. Methods: This retrospective study was made using data from 246 breast cancer patients treated at the Oncology Institute of Vojvodina in the period from January 2010 to December 2015. In all patients nipple sparing mastectomy was performed along with primary breast reconstruction. Results: The mean indication for nipple sparing mastectomy was multicentricity of the tumor (114 patients; 46.3%). The majority of surgically treated patients were in stage II of the disease. The total percentage of local relapses after the nipple sparing mastectomy was 1.6% (4 patients). Total percentage of early complications was 15% (37 patients). Median follow-up after nipple sparing mastectomy was 260 weeks (ranging from 417 to 104 weeks). Conclusion: Primary reconstruction of the breasts using heterologous implants is standard surgical procedure for breast cancer that does not lead to increased number of complications, nor to increased percentage of the local recurrence.
Introduction: Sentinel lymph node biopsy (SLNB) is a standard procedure at the Oncology Institute of Vojvodina since 1999 and during this period we have done more than 1700 biopsies. The aim of this study was to present our results in SLNB in breast cancer surgery. Materials and methods: This retrospective study was performed at the Department for Surgical Oncology at the Vojvodina Institute of Oncology in the period from January 1999 to December 2019. The study included 1762 patients who had undergone SLNB. The mean duration of the follow-up period was 121.89 months. All patients were women with clinically T1-2N0-1M0 breast cancer. Preoperatively, all patients were administered dual contrast media, radiotracer, and blue dye. Results: The majority of tumors were T1c (955 (54.18%). The mean number of extirpated sentinel lymph nodes (SLN) in both groups was 1.84. In 199 (36.72%) patients SLN was the only metastatic lymph node in the axilla. Micro metastases were found in 113 (21.03%) patients. The overall diagnostic accuracy of SLNB was 96%. Conclusion: Axillary SLN can serve as a reliable predictor of negativity of other ipsilateral axillary nodes. Micro metastases in the SLN are not an indication for complete axillary lymph node dissection.
The aim of the study was to check the results of the protocol with neoadjuvant chemoirradiation for the treatment of locally advanced rectal cancer. The value of preoperative methods for staging of rectal cancer was also studied. In the period 1st of June 2000 - 31st of December 2005, 116 patients were included into the study, all with histologically proven rectal cancer up to 12 cm from anal verge and all with T3/T4 No-2 M0 stage. Median follow up was 48 months. Operability rate was 90,1%, local recurrency 12%, and survival 78%, though only 66% without sign of local or distant recurrency.
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