Dermatofibrosarcoma protuberans of the breast: mammographic, ultrasound, MRI and MRS features

Djilas-Ivanovic, Dragana; Prvulović, Nataša; Bogdanović-Stojanović, Dragana; Vicko, Ferenc; Sveljo, Olivera; Ivković-Kapicl, Tatjana

doi:10.1007/s00404-009-1004-5

Cited by 25 publications

(18 citation statements)

References 15 publications

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“…In addition, a lower recurrence rate has also been cited by those who recommend MMS as the treatment of choice. However, larger studies and longer follow-up will be necessary to confirm these findings [5,11,13]. …”

Section: Discussionmentioning

confidence: 99%

Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast

et al. 2010

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Dermatofibrosarcoma protuberans (DFSP) of the breast is exceptionally obscure and late local recurrence of this entity on this site is even more uncommon. We describe such a case in a 48-year-old woman, who at the age of 35 had a DFSP excised from her right breast. Thirteen years later, she developed an ovoid mass in her right breast over the postsurgical scar area. Wide local excision of the tumor with generous tissue margin was performed and microscopic and immunohistochemical findings established the diagnosis of recurrent DFSP. No further treatment was administered and she remains well 18 months later, without tumor recurrence. We report an exceptionally rare case of local recurrence of DFSP in the female breast and discuss in detail the diagnostic and therapeutic implications of this pathology.

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Section: Discussionmentioning

confidence: 99%

Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast

et al. 2010

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“…MR is particularly useful for preoperative planning [ 69 , 78 -80 ]. One case report suggests that a negative choline peak on (1H) MR spectro sccopy (MRS) may be useful in suggesting the diagnosis of DFSP in a highly vascular subcutaneous mass [ 81 ].…”

Section: Imaging Featuresmentioning

confidence: 99%

Soft Tissue Sarcomas

Parham

Kaste

Raju

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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“…When found in the breast region, patients usually undergo only breast ultrasound and mammography without the need for magnetic resonance imaging (MRI) (11). Nevertheless, there is a possibility of the in vivo usage of MR spectroscopy (MRS) that gives additional valuable information of a normal cholin resonance peak which combined with other imaging and pathohistological characteristics can be suggestive of the diagnosis of DFSP (18). Pathological and immunohistochemical examinations are currently the gold standard for diagnosing DFSP (11).…”

Section: Case Reportmentioning

confidence: 99%

A male case of dermatofibrosarcoma protuberans in the breast presenting as gynecomastia

et al. 2021

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Introduction. Dermatofibrosarcoma protuberans (DFSP) is a very rare mesenchymal tumor that accounts for approximately 0.1% of all malignancies. It is a locally aggressive fibrous tumor, with a high recurrence rate, which sometimes gives rise to distant metastases, usually to the bones and lungs. DFSP usually occurs on the trunk and extremities with only a small number of cases in the breast, especially in men. Case report. This paper analyzes a rare case of DFSP in the male breast. A 66-year-old man presented with gynecomastia of the left breast. The diagnostic work-up comprised of clinical examination, ultrasonography, core biopsy, and mammography. Immunohistochemistry revealed diffuse and strong positivity for vimentin, CD99, and CD34, while the tumor cells were completely negative for keratin, S100 protein, STAT6, CD31, and factor VIII, highly suggestive for DFSP. Subsequently, a radical mastectomy was performed and preoperative diagnosis of dermatofibrosarcoma protuberans was confirmed by pathological examination and immunohistochemistry. The patient was still disease-free six months after the surgical treatment. Conclusion. DFSP is a soft tissue sarcoma that rarely occurs in the breast, especially in men. The most common clinical presentation in the breast is a mass, but it can also present as gynecomastia, as in our case.The diagnosis of DFPS is based on anatomopathology with immunohistochemistry analysis since there are no specific imaging features for this rare entity. Surgical excision with wide and negative margins is optimal for reducing the risk of recurrence. Keywords: dermatofibrosarcoma protuberans; male breast; rare; CD34; STAT6; immunohistochemistry Apstrakt Uvod. Dermatofibrosarkom protuberans (DFSP) je veoma redak mezenhimalni tumor koji čini otprilike 0,1% svih maligniteta. To je lokalno agresivni fibrozni tumor, sa velikom stopom recidiva, koji ponekad može dati udaljene metastaze, obično u kosti i pluća. DFSP se obično javlja na trupu i ekstremitetima, dok se samo mali broj slučajeva javlja u dojci, posebno kod muškaraca. Prikaz bolesnika. Ovaj rad analizira retki slučaj DFSP u muškoj dojci. 66-godišnji muškarac je javio sa ginekomastijom leve dojke. Dijagnostička obrada sastojala se od kliničkog pregleda, ultrazvuka, kor biopsije i mamografije. Imunohistohemija je pokazala difuznu i jaku pozitivnost za vimentin, CD99 i CD34, dok su tumorske ćelije bile potpuno negativne na keratin, S100 protein, STAT6, CD31 i faktor VIII, što je sugerisalo da 4 se radi o DFSP. Nakon toga izvršena je radikalna mastektomija i patološkim pregledom i imunohistohemijom dokazana je preoperativna dijagnoza dermatofibrosarkoma protuberans. Pacijent je šest meseci nakon hirurškog lečenja i dalje bio bez bolesti. Zaključak. DFSP je sarkom mekog tkiva koji se izuzetno retko razvija u dojkama muškaraca. Uobičajena klinička prezentacija na dojci jeste masa sa širokim krvžicama na površini, mada se može prezentovati i samo kao ginekomastija, kao u našem slučaju. Dijagnoza DFPS se zasniva na patološkoj anatomiji sa imunoh...

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Dermatofibrosarcoma protuberans of the breast: mammographic, ultrasound, MRI and MRS features

Cited by 25 publications

References 15 publications

Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast

Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast

Soft Tissue Sarcomas

A male case of dermatofibrosarcoma protuberans in the breast presenting as gynecomastia

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