Aims. The frequent use of cannabis by certain social strata often induces behavioral changes whose severity deserves to be evaluated. This study aims to describe the profile of some subjects in a situation of cannabis dependence received at the National Laboratory of Narcotics and Toxicology over the period from January 2016 to December 2021. Methodology. The approach of direct interviews with the respondents using a semistructured questionnaire made it possible to collect their sociodemographic characteristics, their experiences, and their reference trajectories. Results. A total of 48 patients, all single, with an average age of 18.13 ± 0.48 years, the majority of whom were male (77.08%) and of Beninese nationality (85.42%), were enrolled. They were pupils (58.34%), students (27.08%), and workers (14.58%). With a prevalence of consumption of 89.58%, the first experimentation of cannabis was done by imitation (83.3%), among friends (81.2%), and in schools (64.58%). The reasons for use include the search for thrills (29.20%) and the improvement of sexual energy performance (27.1%). Subjects between 64.58 and 79.17% reported having received complaints about their behavior after regular consumption of at least 3 joints of cannabis. Conclusion. The knowledge of the typical profile of subjects in a situation of dependence ensures early detection of problematic uses of cannabis and offers the opportunity to intervene a little earlier in front of this phenomenon.
Background: The use of psychoactive substances among adolescents and young people in schools in Benin is growing despite its consequences on their health. This article analysed this practice, identified the types of use and their determinants along the consumption trajectory.Methods: It was mixed, transversal study and involved 617 students from high schools and colleges in Cotonou and Parakou in 2020. Sampling was in two-degree clusters. 65 students were drawn by reasoned choice and snowball for qualitative interviews. Data processing was done with SPSS software and content analysis.Results: The results show that there was a diversity of substances available, accessible and used by targets in the last three months prior to the survey. Three types of use were identified: experimental use, determined by curiosity (48.14%), the quest for generational identity (25.45%) and sociability (34.20%); misuse, influenced by the quest for physical and sexual performance (17.83%), intellectual performance (28.85%) and peer pressure (22.04%) and dependent use, determined by the precocity of experimentation (69.04%), family type (33.60%) and the relaxation of societal values.Conclusions: Adolescents living in abusive and dependent uses are particularly vulnerable in terms of health and social. This requires a preventive approach based on education in societal values, the fight against the availability of these substances and the early management of cases of dependence.
The use of tramadol by adolescents and young adults in schools is a public health issue. The objectives of this study was to identify students who use tramadol and to investigate the cytochrome CYP2D6 profiles of students at to investigate the potential risks that could be yielded from the usage of tramadol. To achieve this, 453 students participated in the study; R diversity 3.6.1 software in the RStudio environment was used to identify students experimenting with tramadol by calculating a score according to the ASSIST V3.0 tool. The CYP2D6 duplication allele and deletion allele were tested by PCR on DNA extracts from peripheral blood collected from these individuals. Sixty-seven students were found to be using tramadol and of these, 25 students or 37.31% required brief intervention for medical care. Similarly 85.43% of the subjects expressed the CYP2D6 gene. Of these, 7.28% had the duplication allele (CYP2D6dup) and 1.32% the deleted allele (CYP2D6*5). In addition, all subjects at moderate risk due to tramadol use expressed the CYP2D6 gene; the duplication allele (CYP2D6dup) was found in both types of subjects in the proportions of 4% (at risk) and 7.47% (not at risk) respectively. The genetic polymorphism of cytochromes P450 2D6 does not influence tramadol usage by these subjects.
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