Purpose: This study aims to analyze infection control prevention management on nurses' compliance in implementing hand hygiene in the in-patient rooms of Rantauprapat Hospital. Methods: An analytical survey was employed with a cross-sectional design. The population included the nurses who served in the in-patient rooms of Regional General Hospital (RSUD) Rantauprapat with a sample of 64 participants. The data was collected using purposive sampling. For data analysis, univariate, bivariate analysis with chi square and multivariate logistic regression tests were used. Results:The results showed that there is a relationship between infection control prevention management and nurses' compliance in implementing hand hygiene in the in-patient rooms of Rantauprapat Hospital in 2020 with the results of the chi-squares-p = 0.0001 test. In addition, there is a relationship between infection control prevention management based on policy / SPO on nurses’ compliance in implementing hand hygiene in the in-patient rooms of Rantauprapat Hospital in 2020 with the results of the chi-square sig-p = 0.001. The most dominant variable that affects nurses' compliance in implementing hand hygiene is supervision because it has the greatest regression coefficient (B), which is 2.444 with an Exp (B). Conclusion: Based on the results of the study, it is concluded that regular supervision and training serve as the most effective option in infection control prevention management. Moreover, nurses’ compliance with the implementation of hand hygiene in the in-patient rooms of Rantauprapat Hospital has a direct relationship with good infection control prevention management.
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