[Abstract unavailable

Abstract-With the exponential growth of cyber-physical systems (CPS), new security challenges have emerged. Various vulnerabilities, threats, attacks, and controls have been introduced for the new generation of CPS. However, there lack a systematic study of CPS security issues. In particular, the heterogeneity of CPS components and the diversity of CPS systems have made it very difficult to study the problem with one generalized model.In this paper, we capture and systematize existing research on CPS security under a unified framework. The framework consists of three orthogonal coordinates: (1) from the security perspective, we follow the well-known taxonomy of threats, vulnerabilities, attacks and controls; (2)from the CPS components perspective, we focus on cyber, physical, and cyber-physical components; and (3) from the CPS systems perspective, we explore general CPS features as well as representative systems (e.g., smart grids, medical CPS and smart cars). The model can be both abstract to show general interactions of a CPS application and specific to capture any details when needed. By doing so, we aim to build a model that is abstract enough to be applicable to various heterogeneous CPS applications; and to gain a modular view of the tightly coupled CPS components. Such abstract decoupling makes it possible to gain a systematic understanding of CPS security, and to highlight the potential sources of attacks and ways of protection.

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Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa, is undergoing early clinical trials as a novel anticancer agent. However, the anticancer mechanism of curcumin remains to be elucidated. Here we show that curcumin inhibited growth of rhabdomyosarcoma cells (Rh1 and Rh30) (IC 50 5 2-5 lM) and arrested cells in G 1 phase of the cell cycle. Curcumin also induced apoptosis and inhibited the basal or type I insulin-like growth factor-induced motility of the cells. At physiological concentrations (~2.5 lM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela). Curcumin also inhibited phosphorylation of Akt in the cells, but only at high concentrations (>40 lM). The data suggest that curcumin may execute its anticancer activity primarily by blocking mTORmediated signaling pathways in the tumor cells. ' 2006 Wiley-Liss, Inc.

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