Pathogenic bacteria infection is a serious threat to human public health due to the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option to improve the efficiency compared to conventional therapeutic agents. In addition to the drug loading capacity of nanocarriers, which is typically around 10%, further lowers the drug dose that pathological bacteria are exposed to. Moreover, nanocarriers that are not eliminated from the body may cause side effects. These limitations have motivated the development of self-delivery systems that are formed by the self-assembly of different therapeutic agents. In this study, a vehicle-free antimicrobial polymer polyhexamethylene biguanide (PHMB, with bactericidal and anti-biofilm functions) hybrid gold nanoparticle (Au NPs, with photothermal therapy (PTT)) platform (PHMB@Au NPs) is developed. This platform exhibits an excellent synergistic effect to enhance the photothermal bactericidal effect for Staphylococcus aureus under near-infrared irradiation. Furthermore, the results showed that PHMB@Au NPs inhibit the formation of biofilms, quickly remove bacteria to promote wound healing through PTT in infection model in vivo, and even mediate the transition of macrophages from M1 to M2 type, and accelerate tissue angiogenesis. PHMB@Au NPs will have promising value as highly effective antimicrobial agents for patient management.

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A mesoporous carbon nanosphere-intercalated graphene hydrogel with a hierarchical porous architecture is prepared as a flexible quasi-solid-state photothermal supercapacitor via solar irradiation.

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To realize maximum benefits and minimize environment pollution, the eco-efficiency of cultivated land utilization(ECLU) is becoming a vital indicator in weighing the rationality of regional land use. Scientific analysis of spatial-temporal pattern variations, as well as factors influencing the ECLU, is of great significance to cultivated land protection, economic development and ecological environment protection in black soil region of Northeast China, and has become a global strategic issue related to the sustainable development. However, assessments of the indicators are still incomplete, the lack of information may inhabit planning guideline for the sustainable development of cultivated land resources. Thus, this study attempts to fill the gaps by incorporating the net carbon sink and non-point source pollution emissions into the measurement framework of ECLU. The super-efficiency SBM model with undesirable output and the Malmquist-Luenberger(ML) index were used to measure the ECLU and changes in the total factor productivity(TFP) of cultivated land use in the Songnen Plain from 1989 to 2019. Moran index and LISA clustering was used to reveal spatital correlation of ECLU, and Kernel density estimation and trend surface analysis maps were drawn to analyze variation tendency of the ECLU. Geographical detector model was employed to further analyze the influencing factors of ECLU. The study results revealed that:(1)The ECLU showed an overall development trend of "rising first and then declining", all of which were below the frontier efficiency. (2)The polarization of ECLU is prominent, and the ECLU had a significant heterogeneity and spatital correlation. (3)The TFP showing an increasing trend, technological progress is the main driving force to promote the progress of TFP, while the technological efficiency is the bottlenecks for the increasing the TFP of the cultivated land use. (4)According to the magnitude of influencing factor, increasing agricultural science and technology investments, lowering carbon emission, and controlling agrochemical investment could significantly enhance the ECLU. These findings have important implications for promoting high-efficient, low-carbon utilization of cultivated land resources and sustainable regional development in black soil region of Northeast China.

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Hierarchical Ni(OH) nanotubes with ultrathin nanoflakes were successfully synthesized by a self-sacrificial template via a facile solvothermal method. The as-prepared Ni(OH) nanotubes exhibit a high specific capacitance of 1319 F g at 3 A g, and retain 700 F g (79.3% of the initial capacitance) at 5 A g after 7000 cycles.