Key Points
Question
What is the efficacy of a high-dose vaccine schedule compared with standard dosage for hepatitis B virus (HBV) revaccination in patients living with HIV?
Findings
In this randomized clinical trial including 107 adults at a single HIV and hepatology clinic in Chile, 72% of patients receiving a high dose of HBV vaccine achieved serological response as compared with 51% in the standard-dose group. Higher and longer-lasting hepatitis B surface antibody titers were seen in the high-dose group as well.
Meaning
These results suggest that a high-dose regimen may be superior to a standard-dose schedule for HBV revaccination to achieve seroprotection in patients living with HIV.
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