Thirty-nine healthy dogs underwent a simulated radical neck dissection followed by implantation of either 125Iodine (125I) or 192Iridium (192Ir) in various dose regimes randomized prospectively from 3,000 to 30,000 rad. Bilateral selective carotid angiography was performed immediately postoperatively and at six months and one year. No significant effects occurred to the animals who received 15,000 rad 125I or 6,000 rad 192Ir. In the higher dosed animals the 125I treated group fared better than the 192Ir treated group, probably due to the lower dose rate delivery. All surviving animals will be maintained an additional year to determine the late effects of brachytherapy irradiation to the carotid artery.
The article by Leopold and Lagoe1 represents a departure from the high-quality scientific reports we usually see in the ARCHIVES. This departure is welcome and overdue. The authors are to be commended not only for their extensive analysis on diagnosis-related groups (DRGs), but also for having the courage to submit their article to a peer-reviewed journal.
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