Backgound: Stria distensea is considered a destress for the women. Weight gain,family history of stretch marks,steroid use and pregnancy are considered the most common causes of its existance. Striae distensea treatment is considered a challenge, there are different methods in treatment of stria, but till now no single treatment is considered the best treatment for it.Objective: This study aimed to evaluate and compare the effect of dermapen alone and dermapen combined with topical ascorbic acid in treatment of striae distensae. Patients and methods: This study was conducted on 45 patients with stretch marks. Stretch marks treatment in each patient was divided into 2 groups. First group of stretch marks (right side) was treated with dermapen only: 3 sessions with 4 weeks interval. Second group (left side) was treated with dermapen combined with topical ascorbic acid with the same number of sessions. Result: Our study revealed the effectiveness of both methods in treatment of stretch marks, but also it showed a difference in clinical improvement among the two groups concerning change in Manchester Scar Scale (MSS) score after treatment in favor of using dermapen with topical ascorbic acid, which gave better result than using dermapen alone.
Conclusion:The current study concluded that combination of vitamin C and dermapen is promising therapeutic modality with better satisfaction compared to dermapen alone in terms of stretch marks treatment with no adverse events.
Background: Vitiligo is a chronic, acquired depigmenting cutaneous disorder due to damage of melanocytes in genetically susceptible persons. The existence of vitiligo is mediated by the autoimmune dysfunction of cases. CCL20 was expressed at low levels in normal human skin, because both CCL20 and CCR6 were significantly up-regulated within chronic inflammatory cutaneous disorders.CCL20 interacts with its receptor CCR6 to recruit IL-17A-forming cells into skin.Objective: This study was aimed to assess relationship between serum level of CCL20 in cases with vitiligo and its correlation to disease severity and activity Patients and methods: This case-control study included a total of fifty cases with vitiligo and 30 matched age and sex control attending at the outpatient clinic of Dermatology, Mansoura University Hospital. Results: CCL20 levels were considerably greater within vitiligo cases when compared to controls. CCL20 levels were found to be considerably higher in active vitiligo cases in comparison to stable vitiligo cases. Conclusion: It could be concluded that the serum level of CCL20 was demonstrated to be correlated positively with vitiligo-affected patients. Additionally, it seems to have a positive association with disease activity but not with disorder duration so CCL20 could be a candidate as a biomarker to evaluate the activity of vitiligo as well as it is a good predictor of vitiligo and discriminates patients from control.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.