purposeValue co-creation (VCC) recently displayed a significant increase in the frequency of publications in business studies and social sciences. Our study objects to explore the current state of VCC research in the business-to-business (B2B) context, principally in the marketing field.Research design, approach, and methodologyThis research article extracted research papers on VCC in the B2B context published in the last two decades through the Web of Science (WoS). Initially, we applied HistCite to determine the research dynamics of VCC articles and then VOS viewer to conduct bibliographic coupling and cartographic analysis. Furthermore, we found the most co-occurred keywords in the abstracts, titles, and keywords.FindingsOur research explored that the United Kingdom was the most important country with 27 publications and 594 citations. Aarikka-Stenroos L was the most influential author, among his research is a systematic review which revealed that scholars of B2B journals adopted the term business “ecosystem” and studied the implications of ecosystem perspective in business and innovation networks and received the most citations. Industrial Marketing Management (IMM) was the most influential journal because it published 8 of the 10 most cited articles. One hundred and six out of 121 publications were in Business research and seventy-six were in management area, which made it the most hot and critical research area. Lappeenranta University was the most essential organization in VCC research based on the most records published and second-highest citations.Research limitations/implications and future researchFour research streams have emerged which indicate the prominent role of VCC in the B2B context (1) VCC and relationships, (2) VCC and organizational capabilities, (3) VCC and actors’ engagement at various platforms, and (4) VCC and processes. Our research paper provided a base for conceptualizing publications related to business, management, operations research management science, and social sciences interdisciplinary on VCC in the B2B context. Content analysis has revealed that research work on VCC in the B2B context is at an early stage in the marketing arena. Along with bringing some sort of consensus regarding researchers’ opinion toward the nature and modality of VCC literature and process in the B2B context, we urge future research to focus on how relationships and their precursors can be efficiently utilized to co-create and enhance value within B2B interactions. We also request future research to focus on making the VCC process sustainable and viable both on a time and economical basis.Practical implicationsOrganizations can involve customers and producers to work jointly to co-create value for their goods and services with negligible cost to achieve higher market shares and a competitive edge over rivals.Originality/valueThis might be the first bibliometric study conducted on VCC in the B2B context (there are some Bibliometric VCC publications, but they are not B2B-specific, our research is the first Bibliometric study conducted on VCC in the B2B context) in the marketing field and can expose novel avenues for future research.
Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent drugs against glioblastoma. In this study, Asinex 51412372, Asinex 51217461, and Asinex 51216586 were filtered to show the best binding affinity for FGF2 with binding energy scores of −8.3 kcal/mol, −8.2 kcal/mol, and −7.8 kcal/mol, respectively. The compounds showed chemical interactions with several vital residues of FGF2 along the compound length. The noticeable residues that interacted with the compounds were Arg15, Asp23, Arg63, and Gln105. In dynamic investigation in solution, the FGF2 reported unstable dynamics in the first 100 ns and gained structural equilibrium in the second phase of 100 ns. The maximum root mean square deviation (RMSD) value touched by the systems is 3 Å. Similarly, the residue flexibility of FGF2 in the presence of compounds was within a stable range and is compact along the simulation time length. The compounds showed robust atomic-level stable energies with FGF2, which are dominated by both van der Waals and electrostatic interactions. The net binding energy of systems varies between −40 kcal/mol and −86 kcal/mol, suggesting the formation of strong intermolecular docked complexes. The drug-likeness and pharmacokinetic properties also pointed toward good structures that are not toxic, have high gastric absorption, showed good distribution, and readily excreted from the body. In summary, the predicted compounds in this study might be ideal hits that might be further optimized for structure and activity during experimental studies.
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