Ewing's sarcomas (ES) are malignant tumors mostly found in children and young adults 1,2,3. There are only six cavernous sinus ES reported in the literature 1,2,3,4,5. A 21-year-old male presented with diplopia and left VI nerve palsy. Imaging revealed a lesion in the left cavernous sinus (Figure 1). A pretemporal craniotomy was performed with partial resection and recovery. The tumor consisted of small round cells on histopathological examination (Figure 2), positive for CD99, CD56, BCL-2 and Ki 67 positive in 10% of the cells and were negative for desmin, synaptophysin, GFAP, S-100 protein, CLA, cytokeratin 7 and 20, 34BE12, AE1/AE3, consistent with Ewing's sarcoma.
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