Five new monoterpene indole alkaloids
(1–5), including four serpentinine-related
bisindoles and one
alstonine derivative monomer, have been isolated from the aerial parts
of Picralima nitida. Their structures were elucidated
by analysis of their HRMS and NMR spectroscopic data, and their absolute
configurations were deduced from the comparison of experimental and
simulated ECD spectra. In addition, two known compounds (6 and 7), previously undescribed from P. nitida, have also been purified. The compound isolation workflow was guided
by a molecular networking-based dereplication strategy. Twenty-three
compounds were dereplicated from the EtOH extract of P. nitida and fractions network and were assigned various levels of identification
confidence. The antiparasitic activities against Plasmodium
falciparum as well as the cytotoxic activity against the
MRC-5 cell line were determined for compounds 1–7.
Four new saponins, camelliagenin A and B derivatives, and three new secoiridoid glucosides were isolated from the stem bark of Aptandra zenkeri Engl. (Aptandraceae). Their structures were determined based on a combination of 1D-and 2D-NMR experiments techniques and HR-ESI-MS analysis. This is the first report on saponins in genus Aptandra.
Highlights► Five undescribed oleanane-type saponins were isolated from Parkia bicolor.► One undescribed cassane-type diterpene was isolated from Parkia bicolor. ► Their structures were elucidated by 1D-, 2D-NMR and HR-ESI-MS analyses.► Their cytotoxicity against the chronic myeloid leukemia K562 cells was evaluated.
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