Uvaria tortilis is a lianescent annonaceous species endemic to the Côte d'Ivoire where it is used to treat amenorrhea and as uterotonic. Thus, the MeOH crude extract of its stem barks was investigated in order to determine the chemical composition. A new C-benzyl hydroxlated, uvriatortilisin (1), together with six known compounds, dichamanetin (2), β-sitosterol (3), stigmasterol (4), chamanetin (5), uvaretin ( 6) and (-)-epicatechin (7), were isolated. Structure of these compounds was elucidated using spectroscopic techniques, including IR, UV, MS and NMR (1D and 2D). Certain compounds could be considered to have chemotaxonomic value.