Background/aim: Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in AA amyloidosis patients. The reason for the difference in MPV levels in FMF patients with and without AA amyloidosis is unclear. The aim of the study was to determine whether low MPV is unique to AA amyloidosis or MPV is similarly low in all glomerular diseases as a result of proteinuria and/or renal dysfunction. Materials and methods:We compared pre-biopsy MPV levels of patients with AA amyloidosis secondary to FMF, to MPV levels of patients with membranous glomerulonephritis, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy that all present with proteinuria and renal dysfunction.Results: 703 patients (411 male, 292 female) were included in the study. Mean age was 42.6 14.3 years. There were 124 patients with AA amyloidosis, 224 patients with IgA nephropathy, 188 patients with membranous glomerulonephritis, and 167 patients with FSGS. Patients with AA amyloidosis had lower MPV levels compared to patients without AA amyloidosis (7.9 1.2 fL vs. 8.2 0.9 fL respectively, p = 0.008). Patients with AA amyloidosis had significantly lower MPV compared to patients with each of the other diagnoses. Independent predictors of MPV were platelet count (β = -0.321, p < 0.001) and CRP (β = -0.134, p < 0.03). Conclusion:This study is the largest study of MPV in patients with biopsy proven AA amyloidosis and confirms previous studies reporting low MPV in AA amyloidosis. This study indicates that low MPV in AA amyloidosis cannot be explained with proteinuria and renal dysfunction.
Background and Aims Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in amyloidosis patients. The cause of differing MPV levels in FMF patients with and without amyloidosis is not clear. We hypothesized that severe proteinuria and renal dysfunction in amyloidosis could be responsible from low MPV in contrast to FMF patients without amyloidosis. We aimed to compare MPV levels of FMF patients with amyloidosis and MPV values of patients with different glomerular diseases to understand if low MPV is unique to amyloidosis or MPV is similar in all glomerular diseases indicating that it is a consequence of proteinuria and/or renal dysfunction. Method We compared pre-biopsy MPV levels of patients with amyloidosis secondary to FMF, to MPV levels of patients with membranous glomerulonephritis, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy that all present with proteinuria and renal dysfunction. Factors affecting MPV were also determined. Results 703 patients (411 male, 292 female) were included in the study. Mean age was 42.6±14.3 years. There were 124 patients with amyloidosis, 224 patients with IgA nephropathy, 188 patients with membranous glomerulonephritis and 167 patients with FSGS. Patients with amyloidosis had lower MPV compared to patients without amyloidosis (7.9±1.2 fL vs. 8.2±0.9 fL respectively, p=0.008). Patients with amyloidosis had also significantly lower MPV compared to patients with each of the other diagnoses. MPV was negatively correlated with platelet count (r = - 0.351, p <0.001). There was no significant correlation of MPV with serum creatinine and proteinuria. Conclusion This study is the largest study of MPV in patients with biopsy proven amyloidosis and confirms previous studies reporting low MPV in amyloidosis. This study indicates that low MPV in amyloidosis cannot be explained with severe proteinuria and renal dysfunction.
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