Epilepsy is a neurological disease, affecting approximately 50 million people, with a prevalance of 1% in the world (Shokri et al., 2015;Zupec-Kania & Spellman, 2008). Temporal lobe epilepsy is the most common form of this disease (Engel, 2001).Reproductive and sexual function disorders are frequent in male and female patients with epilepsy (Luef & Madersbacher, 2015;Webber et al., 1986). 90% of males with epilepsy were reported to have abnormal sperm count, morphology and motility (Montouris & Morris, 2005). Both epilepsy and antiepileptic drugs play a role in the pathophysiology of reproductive disorders (Herzog, 2008;Rattya et al., 2001). Studies have shown alterations in endocrine system and hormonal levels as a result of epileptiform activity (Hauser & Beghi, 2008;Veliskova & Desantis, 2013). Abnormal serum testosterone and gonadotropin concentrations, abnormal LH response to GnRH stimulation and increased serum prolactin levels were reported to be related to epileptic discharges (Montouris & Morris, 2005).Nigella sativa (N. sativa), belonging to Ranunculaceae family, is a plant frequently used in modern and alternative medicine (Bamosa et al., 2015). Thymoquinone (C 10 H 12 O 2 , 2-isopropyl-5-methyl 1, 4-benzoquinone) is the most important bioactive compound found
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