White sponge nevus is an autosomal dominant skin disorder characterized by white, irregular, diffuse plaques mainly affecting the oral mucosa. Histological findings of white sponge nevus are characteristic but not pathognomonic. We report a case of an oral white sponge nevus in a 6-year-old girl, which poses a problem in differential diagnosis with oral candidiasis. No treatment was performed because of the benign and asymptomatic nature of the lesions.
Hypotrichosis with juvenile macular dystrophy is a rare congenital disease mainly found in Druze population of Northern Israel. This disorder caused by CDH3 mutation encoding P-cadherin, which is expressed in retinal pigment epithelium and hair follicles. A 11-year-old girl was born to related Portuguese parents, had hypotrychosis since birth and macular dystrophy diagnosed at age 5. Fundus examination and fluorescein angiography revealed located macular pigmentary abnormalities. No molecular analysis was done. Fundus examination should be considered as mandatory in the assessment of congenital hypotrichosis.
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