Key Points
Question
Is there evidence for a potential relationship between inflammation and brain structure, and is this relevant for schizophrenia and other neuropsychiatric disorders?
Findings
In this mendelian randomization study including 20 688 participants in the UK Biobank, genetically predicted levels of interleukin 6 were associated with gray matter volume and cortical thickness primarily in the middle temporal gyrus and superior frontal region. The middle temporal gyrus overexpressed a number of genes relevant to interleukin 6 pathway proteins and neuropsychiatric disorder ontologies, including schizophrenia and autism spectrum disorder.
Meaning
This study found that inflammation may be associated with brain structure and may be an early predeterminant of neuropsychiatric conditions, which has important implications for identification of risk and novel treatments.
Purpose The main concern of this research is to examine the indirect effects servant leadership on organisational sustainability (OS) through creativity and psychological resilience in the hoteling sector in Malaysia.Design/methodology/approach A survey method based on a questionnaire was employed to gather data from 441 employees working in the hotel industry in Malaysia. The partial least squares technique, SmartPLS3.3.7, was employed to examine the hypotheses.Findings The result of the study found support for effect of servant leadership on creativity and psychological resilience. In addition, the effect of creativity and psychological resilience on OS was supported. Moreover, the mediation role of creativity and psychological resilience between servant leadership and organisational suitability was also supported by data.Originality/value This is a pioneering study that has combined human capital elements (i.e. servant leadership, creativity and psychological resilience) to examine their impacts on OS. Besides, this work has established comparatively new relationships, i.e. the impact of servant leadership on OS through the mediating role of creativity and psychological resilience. In addition, this study has developed relatively new link between psychological resilience and OS. In addition, it has confirmed the validity and reliability of servant leadership and OS at first and second orders.
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