IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.

Purpose:The purpose of this study was to evaluate the treatment efficacy of vitrectomy combined with subretinal recombinant tissue plasminogen activator (r-tPA) and factors affecting visual improvement in patients with submacular hemorrhage (SMH) due to neovascular age-related macular degeneration (nAMD).Materials and Methods:Medical records of 17 consecutive patients diagnosed with SMH secondary to nAMD were retrospectively reviewed. The initial surgical procedure involved a 23-gauge transconjunctival vitrectomy, subretinal r-tPA application through a self-sealing inferior retinotomy, and sulfur hexafluoride gas for tamponade in all patients. The duration, size, and thickness of the hemorrhage and the pre- and post-operative visual acuity (VA) using a Snellen chart were recorded. VA was converted to logMAR for statistical analysis.Results:The average duration and size of the SMH were 12.8 ± 18.2 days and 8.6 ± 5.3 disc areas, respectively. The mean follow-up time was 16.9 ± 4.7 months. A statistically significant visual improvement was found when comparing initial VA with postoperative best-corrected VA (BCVA) and final BCVA (Wilcoxon rank test, P ≤ 0.01). There was no significant correlation between the size of the hemorrhage and postoperative BCVA and final BCVA (Spearman's rho test). There was no statistically significant correlation between the initial VA and postoperative BCVA and final BCVA (Spearman's rho test). There was no significant correlation between the duration of hemorrhage and postoperative BCVA and final BCVA (Spearman's rho test). The preoperative thickness of hemorrhage (747.5 ± 30 μm) was not correlated with postoperative BCVA or final BCVA (Pearson's test).Conclusions:Vitrectomy combined with subretinal r-tPA injection and gas tamponade is an effective surgical intervention to preserve VA in selected patients with apparent SMH.

The involvement of NADHX repair pathway in KC should be investigated, since preliminary clues obtained in this study point to that direction. In particular, showing the presence of ATP-dependent NAD(P)H-hydrate dehydratase that eliminates NADHX would strengthen our findings and would be a major step toward understanding KC.

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Purpose: To compare the efficacy of gonioscopy-assisted transluminal trabeculotomy combined with cataract surgery (PGATT) and trabeculectomy combined with cataract surgery (PTRAB) in open-angle glaucoma patients.Methods: A multicentered, retrospective, non-randomized study included 67 PGATT patients and 70 PTRAB patients. We compared preoperative intraocular pressure (IOP), best-corrected visual acuity (BCVA) compared with early and final IOP, medication numbers, and BCVA levels. Success was determined as IOP reduction >20% from baseline, IOP between 5-21 mmHg, preoperative IOP of higher than 21 mmHg with medication and postoperative IOP of less than 21 mmHg without medication for surgeries performed for intolerance to medication, postoperative IOP <21 mmHg as well as <18 mmHg separately without medications, and no need for further glaucoma surgery. Results: Preoperative IOP values were 28.61 ± 6.02 mmHg in PTRAB group and 23.99±8.00 mmHg in PGATT group (P<0.0001). Early postoperative IOP values were found lower in PTRAB group as 12.19 ± 3.41 mmHg and as 15.69 ± 4.67 mmHg in PGATT group (P<0.0001). Last follow-up IOP reading were lower in PGATT group (P=0.009). IOP difference values were found higher both in early and last postoperative periods in PTRAB group (respectively, P<0.0001, P=0.018). Success rates were found higher in both at lower than 21 and 18 mmHg levels in PGATT group (respectively, P=0.014, P=0.010).Conclusion: We found the PGATT combined procedure to be a well-tolerated, effective procedure that can lower IOP both early and late in the postoperative period with different rates of IOP success compared with the combined PTRAB procedure.

Amaç Primer açık açılı glokomlu (PAAG) hastalarda optik sinir (OS), optik trakt (OT) ve optik radyasyonda (OR) nörodejenerasyonun tespitinde difüzyon tensör görüntülemenin (DTG) tanı performansını değerlendirmek ve DTG parametreleri ile glokom evresi arasındaki uyumu belirlemek. Gereç veYöntem PAAG'u olan 33 hastanın (17 erkek, 16 kadın, 29-81 yaşında) 65 gözü ve 37 hastalığı bulunmayan gönüllünün 74 gözü çalışmaya dâhil edilmiştir. Çalışmaya katılanlar optik koherens tomografinin de dâhil olduğu tam göz muayenesinden geçirilmiş ve glokom grubu Hodapp-Anderson-Parrish sınıflamasına göre evrelere ayrılmışlardır. Manyetik rezonans görüntüleme tetkiklerinden (MR) elde edilen imajlardan otomatik olarak tensör haritaları oluşturularak ortalama difüzivite (MD), fraksiyonel anizotropi (FA), radyal ve aksiyel difüzivite (RD ve AD) ölçümleri yapılmıştır. İstatistik analizi için SPSS kullanılmıştır. p<0.05 istatistiksel olarak anlamlı kabul edilmiştir. Bulgular Kontrol grubu ile glokomlu hastalar arasında FA, MD ve RD' de OS' de (hepsinde p<0.001) ve OT' da (sırasıyla p<0.001, p<0.001 ve p=0.05) istatistiksel olarak anlamlı farklılık bulunmuş, OR' da ise FA (p=0.611) ve MD' de (p=0.308) anlamlı farklılık izlenmemiştir. Tensör parametrelerinin glokom evrelerine göre karşılaştırılmasında OS FA ile OT FA ve MD değerlerinde tüm evreler ile kontrol grubu arasında anlamlı farklılık saptandı (p≤0,005). Ayrıca retina sinir lifi tabakası kalınlığı ile OS (p<0,001, r=0,555) ve OT FA (p=0,001, r=0,416) ile OT MD (p=0,001, r=0,405) arasında anlamlı korelasyon bulundu. OS 'de FA, MD ve RD ile OT 'da FA ve MD değerlerine ROC analizi yapılmış olup eşik değerler belirlenmiştir. Sonuç DTG parametreleri olan MD, FA ve RD OS ve OT' daki nörodejenerasyonu saptamada ve hastalığın şiddetini belirlemede klinik muayeneyi tamamlayıcı biyomarker olarak kullanılabilecektir.

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