The AcrySof SN60AT Natural IOL provided contrast sensitivity under photopic and scotopic conditions (with and without glare) and blue color perception comparable that obtained with the AcrySof SA60AT IOL. Scotopic vision and blue color discrimination decreased with age with both IOLs.
The performance of an intraocular lens is determined by several factors such as the surgical technique, surgical complications, intraocular lens biomaterial and design, and host reaction to the lens. The factor indicating the biocompatibility of an intraocular lens is the behavior of inflammatory and lens epithelial cells. Hence, the biocompatibility of intraocular lens materials is assessed in terms of uveal biocompatibility, based on the inflammatory foreign-body reaction of the eye against the implant, and in terms of capsular biocompatibility, determined by the relationship of the intraocular lens with residual lens epithelial cells within the capsular bag. Insufficient biocompatibility of intraocular lens materials may result in different clinical entities such as anterior capsule opacification, posterior capsule opacification, and lens epithelial cell ongrowth. Intraocular lenses are increasingly implanted much earlier in life in cases such as refractive lens exchange or pediatric intraocular lens implantation after congenital cataract surgery, and these lenses are expected to exhibit maximum performance for many decades. The materials used in intraocular lens manufacture should, therefore, ensure long-term uveal and capsular biocompatibility. In this article, we review the currently available materials used in the manufacture of intraocular lenses, especially with regard to their uveal and capsular biocompatibility, and discuss efforts to improve the biocompatibility of intraocular lenses.
The increase in SOD activity in the lens capsule of patients with PEX and cataract suggests that oxidative mechanisms play a role in the etiopathogenesis of cataract in PEX. This suggests that SOD activity may be increased as a compensatory mechanism to eliminate this oxidative stress.
Spondylo-ocular syndrome was described by Schmidt et al. [2001]. The findings reported in four affected sibs with consanguineous parents were cataract, crystalline lens malformation, retinal detachment, osteoporosis, and platyspondyly. The authors later published the results of linkage studies analyzing several known genes excluding other conditions involving both the eye and spine [Rudolph et al., 2003]. Therefore, the concurrence of the described ocular and severe vertebral anomalies was proposed as a new entity, possibly recessively inherited.Here, we present an additional case with the unique clinical and radiological findings identical to those described previously confirming that the spondylo-ocular syndrome is a distinct entity.This 5-year-old boy was the second child of a nonconsanguineous couple with a healthy daughter. He was born after an uneventful pregnancy with normal measurements at birth. Bilateral cataract and a harsh murmur were recognized neonatally. He was operated for the cataract at age 1 year, and was followed for the subaortic ventricular septal defect.He was first seen at age of 3 years for inability to walk without support. His weight and height were below 5th centile. He had a 1-year delay in bone age. The radiologic examination showed generalized osteoporosis and platyspondyly. Results of karyotype analysis were normal. His IQ score was 70 (borderline at Stanford-Binet).At age 5 years, he had disproportionate short stature, could speak in sentences, and had been attending special education classes for the last 2 years. He wore glasses for myopia, had facial hypotonia, a long philtrum with thin upper lip, apparently low set ears with thick helices, anti-helix abnormality, and preauricular pits (Fig. 1a). The AP chest diameter was increased, and a pansystolic murmur was heard. Kyphosis, bilateral pes planus, joint hyperextensibility, and smooth hyperelastic skin were noted. He was able to walk and climb up with support from his armpits (Fig. 1b, c).The radiological work-up demonstrated generalized osteoporosis, severe platyspondyly with biconcave, ''cod-fish'' vertebrae, and an increase in intervertebral disc space (Fig. 2). Peripheral blood levels of Ca, P, ALP, and Vitamin D were normal. The diagnosis of spondylo-ocular syndrome were made. Since then, he has been treated for osteoporosis with calcium and Vitamin D supplement. There is improvement in posture and ambulation, and of bone mineral density measurements. He can walk almost independently.The ocular examination and follow-up were performed by one of us (F.K.). The findings at the patient's first visit in infancy were bilateral congenital dense cataract and nystagmus. The visual acuity was light perception in both eyes. Intraocular pressures were normal. Ultrasonographic findings of the globes were normal. Lensectomy, posterior capsulorhexis, and anterior vitrectomy was performed bilaterally. He was followed yearly thereafter.On the most recent examination, visual acuities were 0.2 with correction. He had þ14.00 D aphakic glasse...
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