Background and objective:
Prostate cancer is one of the most widespread cancers among men throughout the world. In addition, it is the second cause of death after lung cancer. Occurrence of the prostate cancer is variable in various regions of the world. Solely, there are three known risk factors for the prostate cancer, including: Age, inheritance and ethnic origin. ELAC2 protein is a phosphodiesterase enzyme encoded by
ELAC2
gene in human. This gene is placed on chromosome 17, and it is believed that product of the mentioned gene is an endonuclease contributed in puberty of mitochondrion’s tRNA. From clinical viewpoint, variables of
ELAC2
gene such as
Ser217Leu
and
Ala541Thr
Missense mutations which are accompanied by hereditary prostate cancer (
HPC2
).Objective of this study is to investigate
Ser217Leu (rs4792311)
and
Ala541Thr (rs5030739)
polymorphisms in the individuals with prostate cancer or those who are suspicious of prostate cancer with family past record/history.
Study method:
In this study conducted by case-control method in 2018, 102 men with prostate cancer and 98 men being suspicious of prostate cancer out of 10 families referred to shahid Rajaei Hospital in Tonekabon county to study and check were investigated. After collection of data using questionnaire, sampling from individuals and performance of the rest steps, study of polymorphism was carried out by PCR sequencing technique, and the results were analyzed by Chromas software.
Finding:
Of the total studied 102 individuals, 44 individuals (43.1%) were homozygote for
Ser217Leu
mutation, 36 individuals (35.2%) were heterozygote and 22 individuals (21.5%) lacked Missense mutation. for Ala541Thr mutation, 18 ones (17.6%) were heterozygote and 84 ones (82.3%) lacked Missense mutation. For
Ser217Leu
mutation, out of 98 suspicious individuals, 21 individuals (21.4%) were homozygote. 6 individuals (6.1%) were heterozygote and 71 individuals (72.4%) lacked the mutation. For Ala541Thr mutation, 15 ones (15.3%) were homozygote and 84 ones (84.6%) lacked the studied mutation.
Conclusion:
Results of this research showed that, in the individuals with the prostate cancer, there is a relationship between
Ser217Leu
and
Ala541Thr
polymorphism of
ELAC2
gene and/with prostate cancer, and the suspicious individuals gotten involved in the mutation must take action to prevent this cancer.
This paper describes the failure mode observed in two types of FCC structural materials: waspaloy and type 316 stainless steel as a result of biaxial low cycle fatigue at elevated temperatures. Torsional cycling was applied at high as well as low strain ranges. Creep effect was assessed by introducing hold periods of 90 seconds in the waspaloy tests and 30 minutes in the stainless steel tests. Data obtained from fatigue and creep-fatigue tests have shown that the failure process in the two materials was controlled by two failure mechanisms which depended, to different degrees, on the state of stress, dwell time, and temperature. The failure mechanisms were assessed by observing crack growth in each material under strain level and temperature. In the waspaloy, the mode of crack growth was more temperature than stress dependent, while in the stainless steel, it was stress dependent. The microstructure analysis showed that each type of crack growth was caused by variations in slip band formation, stages of crack initiation and propagation, secondary cracking and cracking of grain boundaries. Creep showed more interaction with fatigue in the stainless steel material than in the waspaloy.
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