Colorectal cancer (CRC) is one of the most malignant cancer types, characterized by elevated mortality rate and treatment resistance. Despite the progress achieved in the explanation of the molecular basis of the disease as well as introducing potential biomarkers in the clinical practice, further investigation is essential to identify innovative molecules that contribute to colorectal carcinogenesis. Circular RNAs (circRNAs) are a novel and unexplored RNA type, associated with various human pathological conditions. Recently, circRNAs have been identified to be enriched and stable in exosomes and can exert their functions when exosomes reach neighboring or distant cells. Increasing evidence indicates that these so called exosomal circRNAs (exo-circRNAs) act as signaling molecules to regulate cancer proliferation, metastasis, and sensitivity to radio- and chemotherapy. This review aims to discuss the latest progress in exo-circRNAs studies in CRC with an emphasis on their potential as promising diagnostic molecular markers and therapeutic targets.
Current research has shown that neurofeedback (NF) is a viable treatment for attention deficit hyperactivity disorder (ADHD), however having pharmacological approach alongside such stimulants is still inevitable. Therefore, the purpose of this study is the comparison of neurofeedback with Ritalin and without Ritalin in treating children with ADHD. This study was causal-comparative in design. Participants were children aged 5-10 years with ADHD; seven participants were in neurofeedback group with Ritalin and seven in neurofeedback without Ritalin group according to random split and parent's conformation. Clinical Q, Conner's continuous performance test (CPT), and WISC-R were used before and after treatment. For analyzing data, we used descriptive statistical and Mann Whitney U tests. Results showed that even if the two groups were modified in all components, modifications of commission and reaction time of the CPT and F4 theta/alpha of the clinical Q were more accurate in NF with Ritalin treatment rather than the other group. These findings suggest that neurofeedback is efficient in improving some of the behavioral concomitants of ADHD in children whose parents favored non-pharmacological treatment, but Ritalin and neurofeedback combination is more efficient. So, multimodal approach is strongly recommended for ADHD treatment.
Background: According to the World Health Organization (WHO), the high prevalence of breast cancer mortality in the least developed countries is due to the diagnosis at late phases. Accordingly, cost-effective breast cancer screening plans are the most effective methods to control this cancer and increase women’s survival. Methods: This study aimed to evaluate the performance of the breast cancer screening program based on the guidelines of the Iran Ministry of Health on 14,493 eligible women in rural areas of Rudsar city in 2018-19. We calculated performance indicators such as target coverage, identification of the at-risk population, early diagnosis, referral index, and other statistical using SPSS 22 software. Results: Out of 14493 rural women aged 30-59 referred to health homes, 6992 women underwent breast cancer screening. Coverage of the program in the The target population coverage was estimated at 48%. Most high-risk cases were 46 years and older, and the lowest rate was in women of <35 years. We found Thethat results showed that 0.4% of the cases patients (n=27) were identified as the high-risk, and all (100%) referred to group according to the national guidelines with referral to a specialist for further evaluation. of 100%. All patients cases identified as high-risk groups atin the first phase of screening were found with BIRADS (Breast Imaging Reporting and Data System) 4 and 5 based on biopsy specimens. Conclusion: The low target population coverage and the cases with advanced breast cancer indicated the need for more attention and consideration in implementing programs and policies for preventable cancer by all organizations. In this regard, there is a need for relevant interventions and follow-up by health authorities.
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