Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. Exosomes initiate or suppress various signaling pathways in the recipient cells via transmitting heterogeneous cargoes. In this review we discuss exosome biogenesis, exosome mediated metastasis and chemoresistance. Furthermore, tumor derived exosomes role in tumor microenvironment remodeling, and angiogenesis is reviewed. Also, exosome induction of epithelial mesenchymal transition (EMT) is highlighted. More importantly, we discuss extensively how exosomes regulate drug resistance in several cancers. Thus, understanding exosome biogenesis, their contents and the molecular mechanisms and signaling pathways that are responsible for metastasis and drug-resistance mediated by TDEs may help to devise novel therapeutic approaches for cancer progression particularly to overcome therapy-resistance and preventing metastasis as major factors of cancer mortality.

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Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies on multiple factors, including environmental and genetic characteristics. One of the most important environmental factors of GC occurrence is infection with Helicobacter pylori that is classified as class one carcinogens. Dysregulation of several genes and pathways play an essential role during gastric carcinogenesis. Dysregulation of developmental pathways such as Wnt/β-catenin signaling, Hedgehog signaling, Hippo pathway, Notch signaling, nuclear factor-kB, and epidermal growth factor receptor have been found in GC. Epithelial-mesenchymal transition, as an important process during embryogenesis and tumorigenesis, is supposed to play a role in initiation, invasion, metastasis, and progression of GC. Although surgery is the main therapeutic modality of the disease, the understanding of biological processes of cell signaling pathways may help to develop new therapeutic targets for GC.

The integration of computer-based technologies interacting with industrial machines or home appliances through an interconnected network, for teleoperation, workflow control, switching to autonomous mode, or collecting data automatically using a variety of sensors, is known as Internet of Things (IoT). When applied inside an industrial context, it is possible to immediately benefit from the analytics obtained, contributing to process optimization, machine health, the safety of workers and asset management. IoT can assist real-time platforms in remotely monitoring and operating a complex production system with minimal intervention of humans. Hence it can be beneficial for hazardous industries, such as mining, by increasing the safety of personnel and equipment while reducing operation costs. An ideal smart automated mine could potentially be achievable by gradually taking advantage of IoT. Currently, different sensors are used in mine-related activities, such as geophones in exploration and blast control, piezometers in dewatering and toxic gas detectors in working frontlines. However, a fully integrated automated system is challenging in practice due to infrastructural limitations in communication, data management and storage. Moreover, the tendency of mining companies to continue with traditional methods instead of relying on untested novel techniques decelerates this progress. In this study, the adaptability of the mining industry to IoT systems and its current development is reviewed. Significant challenges of this progress are investigated and recommendations to develop a comprehensive model suited for different mining sections such as exploration, operation and safety considering flexible technologies such as Wireless Sensor Networks and the introduction of Global Data Management.

Inspired by the recent successful growth of Ti2C and Ti3C2 monolayers, here, we investigate structural, electronic, and mechanical properties of functionalized Ti2C and Ti3C2 monolayers by means of density functional...

Large-scale underground storage of hydrogen gas is expected to play a key role in the energy transition and in near future renewable energy systems. Despite this potential, experience in underground hydrogen storage remains limited. This work critically reviews the most important elements of this crucial technology, including hydrogen properties and their significance for subsurface operations, sources for hydrogen and historical hydrogen storage operations, to set the state of the art. The cyclical nature of hydrogen storage operations will produce pressure and stress changes within the reservoir that could affect the integrity of the well, the reservoir, the caprock and the entire subsurface storage complex. To minimize geomechanical leakage risks and optimize the storage operation it is crucial to understand the pressure and stress history of the storage site, to optimize well locations to manage pressure and to identify the reservoir-specific cushion gas to working gas ratio. Finally, we outline the major scientific and operational challenges required to ensure the safe and efficient deployment of underground hydrogen storage at a large scale.

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The transport properties of hybrid nanostructures formed by graphene and polyaniline (C3N) are investigated using molecular dynamics simulations. We systematically explored various possible atomic structures of the graphene/C3N interface (IF) and their effects on the interfacial thermal resistance (ITR). Our results initially showed that the zigzag interface yields a far better result than the armchair interface in the thermal transport phenomenon. The effects of temperature and structure length on the ITR were then studied. Our findings show that increasing the temperature from 100 to 600 K and the length from 20 to 120 nm decreases the ITR by 79.5% and 63%, respectively. By applying a 7% strain on the structure, ITR and heat flux increase and decrease by 56% and 15%, respectively, and the temperature jumps by 32%. As the number of defects in the interface increases, the ITR increases significantly. The phonon density of state (PDOS) of the graphene and C3N structures, as well as the atoms in both structures, have been analyzed to properly understand the heat transfer in the interface. Finally, using the von Mises stress formula, the stress distribution and concentration through the sheets and interface in the presence of mechanical strains and various defects are investigated. This work provides valuable information on the phonon behavior of heat transfer in the synthesis of two-dimensional hybrid graphene-based materials for use in nanoelectronic and thermoelectric devices.