Breast cancer (BC) has been recognized as the most common type of cancer in females across the world, accounting for 12% of each cancer case. In this sense, better diagnosis and screening have been thus far proven to contribute to higher survival rates. Moreover, traditional (or standard) chemotherapy is still known as one of the several prominent therapeutic options available, though it suffers from unsuitable cell selectivity, severe consequences, as well as resistance. In this regard, nanobased drug delivery systems (DDSs) are likely to provide promising grounds for BC treatment. Liposomes are accordingly effective nanosystems, having the benefits of multiple formulations verified to treat different diseases. Such systems possess specific features, including smaller size, biodegradability, hydrophobic/hydrophilic characteristics, biocompatibility, lower toxicity, as well as immunogenicity, which can all lead to considerable efficacy in treating various types of cancer. As chemotherapy uses drugs to target tumors, generates higher drug concentrations in tumors, which can provide for their slow release, and enhances drug stability, it can be improved via liposomes in DDSs for BC treatment. Therefore, the present study aims to review the existing issues regarding BC treatment and discuss liposome‐based targeting in order to overcome barriers to conventional drug therapy.

Background & Aim This study aimed to determine health status of Iranian transgender people who referred to Forensic Medicine Center in order to provide equal and accessible health services to transgender people. Materials and methods As part of this cross-sectional study, 200 transsexuals (106 transgender men/TM, 94 transgender women/TW) from Fars Province, Iran, completed a questionnaire including 24 items on socio-demography and health status in 2021. The data were analyzed using SPSS version 16, and also Chi-square test and Fisher's exact test were used for the data analysis. A p-value < 0.05 was considered statistically significant. Results The gender identity age distribution was significantly different between TW and TM (P = 0.004). Women were significantly more likely to engage in unprotected intercourse than men (p = 0.001), but perceived financial, medical, and social barriers were not significantly different between the two groups (P > 0.05). However, women reported more family obstacles than men (P = 0.006). Conclusion Both women and men have experienced equal financial, medical, and social challenges in the health system, but women face more constraints in their family lives.