Background Medical records on multiple sclerosis progression is not complete. This study aimed to review the medical records and sociodemographic findings of the multiple sclerosis population in Mazandaran province. Method This case-control study included cases and two groups of patient control and healthy control groups (n=200 per group). Multivariable analysis was used to calculate odds ratios and 95% confidence intervals (CI). Result The participants’ mean age was 36.5 ± 11.9 years, and there were 381 (63.5%) female cases in this study. According to adjusted odds ratios, the highest and the lowest roles for the multiple sclerosis progression included measles (4.40; 95% CI: 1.73 to 11.1), psoriasis (4.63; 95% CI: 0.35 to 60.6), myasthenia gravis (7.15; 95% CI: 1.87 to 27.2) and amoxicillin (4.75; 95% CI: 2.05 to 11), seizure (0.14; 95% CI: 0.03 to 0.69), and epilepsy (0.17; 95% CI: 0.02 to1.49). Conclusion Myasthenia gravis and seizure had the highest and lowest association with multiple sclerosis, respectively. Hence, this study implied that autoimmune diseases were more frequently correlated with the multiple sclerosis progression.
This project sought to explore the potential association between medical history and the development of multiple sclerosis (MS) by conducting a retrospective study. This population-based case-control study included 200 MS cases and 2 control groups of 200 patients and healthy individuals each. Data was collected through face-to-face interviews, medical file reviews, and an electronic checklist. Multivariable analysis was used to calculate odds ratios and 95% confidence intervals to estimate the risk of each medical history on MS occurrences. Of 600 participants, 381 (63.5%) individuals were female. The mean age of the participants was 36.5 ± 11.9 years. The adjusted risks of MS were 4.40; 95% CI: 1.73 to 11.1 for measles and 4.75; 95% CI: 2.05 to 11 for amoxicillin consumption. The adjusted MS odds for autoimmune disease including 4.63; 95% CI: 0.35 to 60.6 for psoriasis and 7.15; 95% CI: 1.87 to 27.2 for myasthenia gravis. On the other hand, the calculated adjusted odds of MS occurrence were 0.14; 95% CI: 0.03 to 0.69 for seizure and 0.17; 95% CI: 0.02 to 1.49 for epilepsy. This study suggested that individuals with autoimmune diseases should be monitored more closely, as they may be at an increased risk of developing other autoimmune conditions, particularly MS.
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