Medical records and multiple sclerosis: A population-based case–control study

Abstract

Background Medical records on multiple sclerosis progression is not complete. This study aimed to review the medical records and sociodemographic findings of the multiple sclerosis population in Mazandaran province. Method This case-control study included cases and two groups of patient control and healthy control groups (n=200 per group). Multivariable analysis was used to calculate odds ratios and 95% confidence intervals (CI). Result The participants’ mean age was 36.5 ± 11.9 years, and there were 381 (63.5%) female cases in this study. According to adjusted odds ratios, the highest and the lowest roles for the multiple sclerosis progression included measles (4.40; 95% CI: 1.73 to 11.1), psoriasis (4.63; 95% CI: 0.35 to 60.6), myasthenia gravis (7.15; 95% CI: 1.87 to 27.2) and amoxicillin (4.75; 95% CI: 2.05 to 11), seizure (0.14; 95% CI: 0.03 to 0.69), and epilepsy (0.17; 95% CI: 0.02 to1.49). Conclusion Myasthenia gravis and seizure had the highest and lowest association with multiple sclerosis, respectively. Hence, this study implied that autoimmune diseases were more frequently correlated with the multiple sclerosis progression.