Experiments carried out on mice demonstrated that administration of a platinum-based drug, cisplatin, extensively used in anticancer chemotherapy, exerts significant hyperalgesic effects; it intensifies both phases of pain behavioral reactions induced in the formalin test. When introduction of cisplatin was combined with i.p. injections of 100 mg/kg of an aqueous-alcoholic extract from the leaves of Salvia officinalis, the second phase of cisplatin-enhanced pain in the formalin test was effectively suppressed; the effect was comparable with that provided by injections of morphine or even more intense.
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