Study of Matricaria recutita and Vincristine Effects on PTZ-Induced Seizure Threshold in Mice

A, Ali Namvaran; No, Mir Hadi Khayate; Tavakkoli, Farzaneh

doi:10.3923/rjmsci.2011.247.251

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…More than one third of Americans use herbs for health purposes, yet patients (and physicians) often lack accurate information about the safety and efficacy of herbal remedies (Khayat Nouri, 2011;O'Hara et al, 1998). Previous study have shown that Matricaria Chamomilla could be useful in Cisplatin-induced neurotoxicity (Namvaran et al, 2011a) Matricaria Chamomilla (MC) is the herb that is used for sedation, pain management, antispasmodic, anticonvulsant, anti inflammatory, antipyretic, wound healing, and antioxidant agent in traditional medicine (Berry, 1995;Kyokong et al, 2002;Mills, 1991;Namvaran and Khayate, 2011;Namvaran et al, 2011c;Norman, 2001;Trease and Evans, 1982;Wong et al, 1998). MC powder is aromatic, yellowish green in color and bitter taste.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Nouri¹

2012

Afr. J. Pharm. Pharmacol.

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Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus, effective therapeutic strategy is required. In this study, the antinociceptive effect of Matricaria chamomilla (MC) hydroalcoholic extract and morphine on vincristine-induced peripheral neuropathy model in mice has been investigated. Experiments were performed on 60 Naval Medical Research Institute (NMRI) male mice. Mouse subsequently received daily intraperitoneal and intravenal injections of vincristine sulfate, saline and MC hydroalcoholic extract over 12 days, immediately following behavioral testing. For assessment of pain, formalin test was preformed. The effects of MC, morphine and vehicle (saline) 30 min before formalin test on vincristine-induced neuropathy were evaluated. Administration of MC before formalin injection showed significant (P < 0.05) decrease of pain responses in both phases. Administration of vincristine produced significant (Pm < 0.05) increase in pain response in second phase of formalin test. Injection of MC and vincristine together has shown that MC is able to decrease the vincristine induced pain significantly (P < 0.05). Morphine decreased vincristine induced pain test significantly (P < 0.05). In comparison, morphine has analgesic effects in the first phase and MC has anti-inflammatory effects in the second phase of formalin test significantly (P < 0.05). These results suggest that MC may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.

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Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Nouri¹

2012

Afr. J. Pharm. Pharmacol.

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Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

Namvaran-Abbas-Abad

Tavakkoli

2012

Neurophysiology

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Experiments carried out on mice demonstrated that administration of a platinum-based drug, cisplatin, extensively used in anticancer chemotherapy, exerts significant hyperalgesic effects; it intensifies both phases of pain behavioral reactions induced in the formalin test. When introduction of cisplatin was combined with i.p. injections of 100 mg/kg of an aqueous-alcoholic extract from the leaves of Salvia officinalis, the second phase of cisplatin-enhanced pain in the formalin test was effectively suppressed; the effect was comparable with that provided by injections of morphine or even more intense.

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Anticonvulsant activity of Iranian medicinal plants and molecular docking studies of isolated phytochemicals

Zadali

Baghery

Abbasi

et al. 2022

South African Journal of Botany

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Study of Matricaria recutita and Vincristine Effects on PTZ-Induced Seizure Threshold in Mice

Cited by 5 publications

References 9 publications

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

Anticonvulsant activity of Iranian medicinal plants and molecular docking studies of isolated phytochemicals

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