Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Abstract

Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus, effective therapeutic strategy is required. In this study, the antinociceptive effect of Matricaria chamomilla (MC) hydroalcoholic extract and morphine on vincristine-induced peripheral neuropathy model in mice has been investigated. Experiments were performed on 60 Naval Medical Research Institute (NMRI) male mice. Mouse subsequently received daily intraperitoneal and intravenal injections of vincristine sulfate, saline and MC hydroalcoholic extract over 12 days, immediately following behavioral testing. For assessment of pain, formalin test was preformed. The effects of MC, morphine and vehicle (saline) 30 min before formalin test on vincristine-induced neuropathy were evaluated. Administration of MC before formalin injection showed significant (P < 0.05) decrease of pain responses in both phases. Administration of vincristine produced significant (Pm < 0.05) increase in pain response in second phase of formalin test. Injection of MC and vincristine together has shown that MC is able to decrease the vincristine induced pain significantly (P < 0.05). Morphine decreased vincristine induced pain test significantly (P < 0.05). In comparison, morphine has analgesic effects in the first phase and MC has anti-inflammatory effects in the second phase of formalin test significantly (P < 0.05). These results suggest that MC may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.

Descriptive study of contemporary status of the traditional knowledge on medicinal plants in Bulgaria

“…The application that we registered is basically relevant to the records that have been published for Bulgarian traditional and official medicine which relays on medicinal plants (Petkov, 1982;Mitrev and Popova, 1982;Pamukov, 1992;Dimkov, 2001;Nikolov, 2006). Some of the well known data initiate modern detailed research like for instance the antinociceptive effect of M. chamomilla (Nouri and Abad, 2012).…”

Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients

“…The essential oils reported to have potential effects on neuropathic pain were chosen based on the literature (Abad et al., ; Ali et al., ; Begum et al., ; Buckle, ; Ghasemzadeh et al., ; Koulivand et al., ; Li, ; Lucarini et al., ; Motilal & Maharaj, ; Nouri & Abad, ; Saeki, ) and on an expert opinion from a certified aromatherapist working in the Drug Development and Pharmacokinetic Research Application Center at Ege University in Turkey.…”

“…Rosemary (Rosmarinus officinalis), geranium (Pelargonium graveolens), and chamomile (Chamaemelum recutita) have analgesic, antinociceptive, anti‐inflammatory, antineuralgic, and muscle‐relaxing effects; lavender (Lavandula angustifolia) and eucalyptus (Eucalyptus citriodora) have similar properties, including analgesic, neuroprotective, anti‐inflammatory, and muscle‐relaxing effects (Abad, Nouri, Gharjanie, & Tavakoli, ; Ali et al., ; Begum, Sandhya, Vinod, Reddy, & Banji, ; Ghasemzadeh, Amin, Mehri, Mirnajafi‐Zadeh, & Hosseinzadeh, ; Koulivand, Khaleghi Ghadiri, & Gorji, ; Lucarini et al., , Motilal & Maharaj, ). Several systematic reviews, preclinical trials, and case reports suggest that rosemary, geranium, lavender, eucalyptus, and chamomile show promising effects on alleviating the severity of neuropathic pain (Abad et al., ; Ali et al., ; Begum et al., ; Ghasemzadeh et al., ; Koulivand et al., ; Li, ; Lucarini et al., ; Motilal & Maharaj, ; Nouri & Abad, ).…”

Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial

“…In addition, chamomile has been used for alleviating rheumatic and arthritis pain by different TMs (16). Chamomile is a rich source of terpenoids and flavonoids (17) and can possess anti-inflammatory, antioxidant (18) and antinociceptive (19) effects. In addition, chamomile is a safe medicinal herb, and especially there were several reports on its external use for a variety of diseases on different sites of the human body (20).…”