We investigated the effectiveness of the mass measles vaccination campaign in Urmia, Islamic Republic of Iran, by examining the measles IgG seroprevalence and antibody response from paired data before and after the campaign. The overall seropositive rate of 624 subjects aged 5-25 years increased 1 year after the mass vaccination (from 53.0% to 72.3%). A rise in antibody titre occurred in all age groups except the 21-25 years group, which had the highest titre before mass vaccination. On logistic regression analysis, only immune status prior to vaccination was significantly associated with the seroresponse. It may be cost-effective to check antibody titres before mass vaccinations, especially in high vaccine coverage regions with circulating wild virus. ‫ﺍﻹﺳﻼﻣﻴﺔ‬ ‫ﺇﻳﺮﺍﻥ‬ ‫ﺑﺠﻤﻬﻮﺭﻳﺔ‬ ‫ﺃﻭﺭﻣﻴﺎ،‬ ‫ﰲ‬ ‫ﺍﳉﻤﻮﻋﻲ‬ ‫ﺍﻟﺘﻠﻘﻴﺢ‬ ‫ﺑﻌﺪ‬ ‫ﺍﳊﺼﺒﺔ‬ ‫ﻟﻠﻘﺎﺡ‬ ‫ﺍﳌﻨﺎﻋﻴﺔ‬ ‫ﺍﻻﺳﺘﺠﺎﺑﺔ‬

Background: Ulcerative colitis is one type of inflammatory bowel disease. Objectives: The aim of this study was to investigate the prevalence of cytomegalovirus in patients with ulcerative colitis in comparison with healthy subjects by using PCR technique. Patients and Methods:In this analytical case-control study, 5 patients with ulcerative colitis and 30 patients without malignancy as controls were selected. Biopsy specimens were frozen under sterile conditions at -20ºC. After DNA extraction, analysis of polymerase chain reaction (PCR) to detect CMV DNA in tissue samples was performed. Statistical analysis was performed with χ2 test. Results: CMV DNA was found in 80% of ulcerative colitis samples (4 of 5) and 30% of the non-malignant control group (9 of 30). Statistical analysis showed significant association between the prevalence of CMV and incidence ulcerative colitis in comparison with the control group (P = 0.03). Conclusions:The results of the present study has shown ulcerative colitis patients have a predisposition to CMV infection as compared to healthy individuals, but the etiologic link between ulcerative colitis and CMV infection needs to be studied.

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Analysis of colorectal cancer and polyp for presence herpes simplex virus and cytomegalovirus DNA sequences by polymerase chain reaction.