Immune response to measles vaccine after mass vaccination in Urmia, Islamic Republic of Iran

Yekta, Zahra; Pourali, Reza; Taravati, M R; Shahabi, Shahram; Salary, S; Khalily, Farzad; Farzin, Azadeh

doi:10.26719/2009.15.3.516

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…An additional dose of measles antigen during the schoolgoing age or later to boost the individual as well as herd immunity against measles can be seen as a possible solution to counteract waning immunity. On the contrary, Yekta et al 23 reported higher seropositivity and higher mean titres of measles antibody in children who received single vaccination as compared to those who were vaccinated twice against measles ( P <0.05). This can be explained by the fact that pre-immunization antibody level is inversely correlated with the response to vaccination i.e., children with low pre-immunization antibody titres show strong response2024.…”

Section: Discussionmentioning

confidence: 92%

Seroprevalence of measles, mumps & rubella antibodies among 5-10 years old children in north India

et al. 2019

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Background & objectives: Globally, there is an effort to eliminate the measles and control rubella as these diseases lead to considerable morbidity and mortality especially among under-five children and are important public health problems. This study was aimed to estimate the seroprevalence of measles, mumps and rubella (MMR) antibodies among children of age 5-10 yr in Chandigarh, north India, to provide evidence on prevalent immunity levels. Methods: This cross-sectional study was conducted in Chandigarh, among 196 randomly selected healthy children (5-10 yr), who received either one or two doses of measles or MMR combination vaccine. Socio-economic background and immunization history were recorded. Blood sample (2 ml) was collected to estimate the MMR IgG antibody titres by using ELISA kits. Results: Protective seroprevalence of MMR antibodies was 40.8, 75.5 and 86.2 per cent, respectively. The geometric mean titres of MMR IgG antibodies in the study children were 11.3, 50.6 and 54.3 international units (IU)/ ml, respectively. The proportion of seroprotected children for measles was significantly higher among those who had received two or more doses (46.4%) of measles vaccine compared to those who had received single dose (35.6%) ( P <0.001). About 16 per cent of children had received single dose of MMR vaccine. Among these, 71.4 and 100 per cent were seroprotected against mumps and rubella, respectively. Interpretation & conclusions: A large proportion of children aged 5-10 yr lacked protective immunity against measles (60%); about one-fourth (15-25%) were susceptible to infection with mumps and rubella virus. Mumps vaccination may be considered to be included in National Immunization Schedule for children with periodic serosurveillance.

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Section: Discussionmentioning

confidence: 92%

Seroprevalence of measles, mumps & rubella antibodies among 5-10 years old children in north India

et al. 2019

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“…However, these levels of immunity for measles were significantly lower than the rates required to achieve 95% coverage or higher, the target required for elimination [11]. A survey in Urmia (northern Iran) showed that measles immunity in the population aged 5 to 25 years increased from 53% before to 72.3% after the 2003 mass vaccination campaign [35]. The present study showed that 81.7% of pregnant women were immune against measles, a figure similar to those in other countries.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Anti-Rubella and Anti-Measles IgG Antibodies in Pregnant Women in Shiraz, Southern Iran: Outcomes of a Nationwide Measles-Rubella Mass Vaccination Campaign

et al. 2013

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ObjectiveNonimmune pregnant women are at risk of developing congenital rubella syndrome and measles complications. We aimed to identify pregnant women susceptible to rubella or measles in order to determine the need for immunity screening and supplemental immunization in women of childbearing age.MethodThis seroprevalence survey was conducted by convenience sampling in obstetric hospitals affiliated with Shiraz University of Medical Sciences (southern Iran). Serum IgG levels were measured by ELISA.ResultMean age of the 175 pregnant women was 27.3±5.3 (range 16 to 42) years. The geometric mean concentration of anti-rubella IgG was 14.9 IU/mL (CI 95%,14.1–15.5), and that of anti-measles IgG was 13.8 IU/mL (CI 95%, 13–14.5). One hundred sixty-eight women (96%) had a protective serologic level (>11 IU/mL) of IgG against rubella, and 143 (81.7%) had a protective level against measles. Except for a significant inverse correlation that was showed by univariate analysis between anti-rubella IgG and the women’s age (P = 0.01), immunity did not correlate with demographic or obstetric characteristics or medical history. There was no significant correlation between anti-rubella and anti-measles IgG levels (P = 0.25).ConclusionNearly a decade after Iran’s nationwide measles-rubella vaccination campaign for the population aged 5–25 years, most pregnant women up to 34 years of age had humoral immunity against rubella. We recommend rubella immunity screening or catch-up immunization for women older than 35 years who wish to become pregnant, and measles immunity screening and appropriate vaccination for all women of childbearing age.

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“…We identified over 220 studies that provided cross‐sectional data and nearly 180 studies that reported on immunity for women of child‐bearing age, primarily for rubella. Table summarizes the over 400 cross‐sectional and women of child‐bearing age measles and rubella serological studies…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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Serological tests provide information about individual immunity from historical infection or immunization. Cross-sectional serological studies provide data about the age- and sex-specific immunity levels for individuals in the studied population, and these data can provide a point of comparison for the results of transmission models. In the context of developing an integrated model for measles and rubella transmission, we reviewed the existing measles and rubella literature to identify the results of national serological studies that provided cross-sectional estimates of population immunity at the time of data collection. We systematically searched PubMed, the Science Citation Index, and references we identified from relevant articles published in English. We extracted serological data for comparison to transmission model outputs. For rubella, serological studies of women of child-bearing age provide information about the potential risks of infants born with congenital rubella syndrome. Serological studies also document the loss of maternal antibodies, which occurs at different rates for the different viruses and according to the nature of the induced immunity (i.e., infection or vaccine). The serological evidence remains limited for some areas, with studies from developed countries representing a disproportionate part of the evidence. The collection and review of serological evidence can help program managers identify immunity gaps in the population, which may help them better understand the characteristics of individuals within their populations who may participate in transmission and manage risks.

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Immune response to measles vaccine after mass vaccination in Urmia, Islamic Republic of Iran

Cited by 10 publications

References 29 publications

Seroprevalence of measles, mumps & rubella antibodies among 5-10 years old children in north India

Seroprevalence of measles, mumps & rubella antibodies among 5-10 years old children in north India

Seroprevalence of Anti-Rubella and Anti-Measles IgG Antibodies in Pregnant Women in Shiraz, Southern Iran: Outcomes of a Nationwide Measles-Rubella Mass Vaccination Campaign

Systematic Review of Measles and Rubella Serology Studies

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