Rank annihilation factor analysis (RAFA) was used for the spectrophotometric studies of complex formation between a new Schiff base derived from 3,6-bis((aminoethyl)thio)pyridazine and some transition metals in dimethylformamide (DMF). Formation constants of these complexes were derived using RAFA on spectrophotometric data. According to molar ratio data and Job's plot, the stoichiometry of complexation between the Schiff base and the Ni 2+ , Co 2+ , Cu 2+ , and Zn 2+ cations was 1:1 and for Pd 2+ was 2:1. The logarithm of the complex formation constants was found to be 5.66 for Ni 2+ , 5.1 for Co 2+ , 7.08 for Cu 2+ , 6.73 for Zn 2+ , and 7.77 for Pd 2+ .

Background:Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity.Materials and Methods:Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured.Results:In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx.Conclusion:M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.

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